Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3753041..3753878 Replicon chromosome
Accession NZ_LR882978
Organism Escherichia coli isolate L3_CS7_E2980

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag JLZ94_RS18420 Protein ID WP_000227784.1
Coordinates 3753336..3753878 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag JLZ94_RS18415 Protein ID WP_001297137.1
Coordinates 3753041..3753352 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ94_RS18390 3748061..3749008 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
JLZ94_RS18395 3749030..3751021 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
JLZ94_RS18400 3751011..3751625 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
JLZ94_RS18405 3751625..3751954 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
JLZ94_RS18410 3751966..3752856 + 891 WP_000971336.1 heme o synthase -
JLZ94_RS18415 3753041..3753352 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
JLZ94_RS18420 3753336..3753878 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
JLZ94_RS18425 3753934..3754869 - 936 WP_001387350.1 sel1 repeat family protein -
JLZ94_RS18430 3755277..3756641 + 1365 WP_001000965.1 MFS transporter -
JLZ94_RS18435 3756769..3757260 - 492 WP_001138904.1 nucleotide binding protein YajQ -
JLZ94_RS18440 3757428..3758339 + 912 WP_000705865.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T290033 WP_000227784.1 NZ_LR882978:3753336-3753878 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT290033 WP_001297137.1 NZ_LR882978:3753041-3753352 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References