Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2513582..2515170 Replicon chromosome
Accession NZ_LR882978
Organism Escherichia coli isolate L3_CS7_E2980

Toxin (Protein)


Gene name hipA Uniprot ID F4NFZ0
Locus tag JLZ94_RS12425 Protein ID WP_001125463.1
Coordinates 2513848..2515170 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag JLZ94_RS12420 Protein ID WP_001296726.1
Coordinates 2513582..2513848 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ94_RS12420 2513582..2513848 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
JLZ94_RS12425 2513848..2515170 + 1323 WP_001125463.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
JLZ94_RS12430 2515430..2515792 - 363 WP_095892504.1 hypothetical protein -
JLZ94_RS12435 2515795..2516193 - 399 WP_000981410.1 hypothetical protein -
JLZ94_RS12440 2516278..2516730 - 453 WP_000069317.1 transcriptional regulator -
JLZ94_RS12445 2516898..2517950 + 1053 WP_001386054.1 phage/plasmid replication protein, II/X family -
JLZ94_RS12450 2517962..2518105 + 144 WP_001386055.1 hypothetical protein -
JLZ94_RS12455 2518109..2518561 - 453 WP_000069317.1 transcriptional regulator -
JLZ94_RS12460 2518709..2519818 + 1110 Protein_2440 type II secretion system protein GspD -
JLZ94_RS12465 2519907..2520155 + 249 WP_001388362.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(7-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49422.05 Da        Isoelectric Point: 9.1203

>T290031 WP_001125463.1 NZ_LR882978:2513848-2515170 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT290031 WP_001296726.1 NZ_LR882978:2513582-2513848 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9IYX0

Antitoxin

Source ID Structure

References