Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1458205..1458830 Replicon chromosome
Accession NZ_LR882978
Organism Escherichia coli isolate L3_CS7_E2980

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag JLZ94_RS07185 Protein ID WP_000911329.1
Coordinates 1458432..1458830 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag JLZ94_RS07180 Protein ID WP_000450524.1
Coordinates 1458205..1458432 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ94_RS07155 1454007..1454477 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
JLZ94_RS07160 1454477..1455049 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
JLZ94_RS07165 1455195..1456073 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
JLZ94_RS07170 1456090..1457124 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
JLZ94_RS07175 1457337..1458050 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
JLZ94_RS07180 1458205..1458432 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
JLZ94_RS07185 1458432..1458830 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
JLZ94_RS07190 1458977..1459840 + 864 WP_001267498.1 neutral zinc metallopeptidase -
JLZ94_RS07195 1459855..1461870 + 2016 WP_001388162.1 tRNA cytosine(34) acetyltransferase TmcA -
JLZ94_RS07200 1461944..1462642 + 699 WP_000679812.1 esterase -
JLZ94_RS07205 1462723..1462923 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T290025 WP_000911329.1 NZ_LR882978:1458432-1458830 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT290025 WP_000450524.1 NZ_LR882978:1458205-1458432 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References