Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 46775..47610 Replicon chromosome
Accession NZ_LR882973
Organism Escherichia coli isolate L2_E1649

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag JLZ81_RS00235 Protein ID WP_000854743.1
Coordinates 46775..47152 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag JLZ81_RS00240 Protein ID WP_001285298.1
Coordinates 47242..47610 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLZ81_RS00210 42133..43056 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
JLZ81_RS00215 43167..44351 - 1185 WP_001172882.1 sugar efflux transporter -
JLZ81_RS00220 45146..45984 - 839 Protein_43 DUF4942 domain-containing protein -
JLZ81_RS00225 46081..46278 - 198 WP_000839275.1 DUF957 domain-containing protein -
JLZ81_RS00230 46290..46778 - 489 WP_000761693.1 hypothetical protein -
JLZ81_RS00235 46775..47152 - 378 WP_000854743.1 TA system toxin CbtA family protein Toxin
JLZ81_RS00240 47242..47610 - 369 WP_001285298.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
JLZ81_RS00245 47660..48304 - 645 WP_000086754.1 hypothetical protein -
JLZ81_RS00250 48323..48544 - 222 WP_000692295.1 DUF987 domain-containing protein -
JLZ81_RS00255 48613..49089 - 477 WP_032328266.1 RadC family protein -
JLZ81_RS00260 49104..49589 - 486 WP_097344122.1 antirestriction protein -
JLZ81_RS00265 49681..50502 - 822 WP_001706654.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14172.08 Da        Isoelectric Point: 6.8519

>T289997 WP_000854743.1 NZ_LR882973:c47152-46775 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDSVNFLVEKYALVRTDQPGF
GACTYSQLINSIDILRARRATGLMTRDNYRTVNDITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13710.44 Da        Isoelectric Point: 5.8799

>AT289997 WP_001285298.1 NZ_LR882973:c47610-47242 [Escherichia coli]
MSDSRHETNYPDDHNDRPWWGLPCTVIPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKN

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References