Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 3218762..3219339 Replicon chromosome
Accession NZ_LR882967
Organism Planktothrix pseudagardhii strain No.713

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NMK36_RS13680 Protein ID WP_254173966.1
Coordinates 3218762..3219103 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1J1LPA2
Locus tag NMK36_RS13685 Protein ID WP_072720577.1
Coordinates 3219097..3219339 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK36_RS13660 (NO713_02729) 3214695..3214964 - 270 WP_072720572.1 hypothetical protein -
NMK36_RS13665 (NO713_02730) 3215307..3215912 + 606 WP_190522800.1 NfeD-like protein -
NMK36_RS13670 (NO713_02731) 3216001..3217329 + 1329 WP_254173964.1 SPFH domain-containing protein -
NMK36_RS13675 (NO713_02732) 3217382..3218701 + 1320 WP_254173965.1 SPFH domain-containing protein -
NMK36_RS13680 (NO713_02733) 3218762..3219103 - 342 WP_254173966.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NMK36_RS13685 (NO713_02734) 3219097..3219339 - 243 WP_072720577.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NMK36_RS13690 (NO713_02735) 3219545..3220468 - 924 WP_072720578.1 ornithine carbamoyltransferase -
NMK36_RS13695 (NO713_02736) 3220635..3221660 - 1026 WP_254173967.1 tRNA dihydrouridine synthase DusB -
NMK36_RS13700 (NO713_02737) 3221757..3222044 + 288 WP_139295122.1 hypothetical protein -
NMK36_RS13705 (NO713_02738) 3222065..3223366 - 1302 WP_254173968.1 cyclic nucleotide-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-111)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12932.06 Da        Isoelectric Point: 6.2191

>T289994 WP_254173966.1 NZ_LR882967:c3219103-3218762 [Planktothrix pseudagardhii]
MVNQSYIPDRGHIVKLNFNPTQGHEQKGLRPAFVISPYEYNVKNSLALFMPITAQVKGYPFEVSLPSELTTYGVILVDHI
KSLDYKVRLIQFIEIVPEDVIQEVQAKIEVLIF

Download         Length: 342 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8769.86 Da        Isoelectric Point: 4.9313

>AT289994 WP_072720577.1 NZ_LR882967:c3219339-3219097 [Planktothrix pseudagardhii]
MVTNVAKWGNSLAVRIPQNIAQAIQISEGSQVTFSVENGTIVIKPSNRKRYSLEELVSQITPENCHTETDTGLAVGNEVW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1J1LPA2

References