Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2273217..2273830 Replicon chromosome
Accession NZ_LR882967
Organism Planktothrix pseudagardhii strain No.713

Toxin (Protein)


Gene name vapC Uniprot ID A0A7Z9BN42
Locus tag NMK36_RS09550 Protein ID WP_072722242.1
Coordinates 2273217..2273603 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7Z9BU65
Locus tag NMK36_RS09555 Protein ID WP_072722241.1
Coordinates 2273600..2273830 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NMK36_RS09540 (NO713_01905) 2268616..2269695 + 1080 WP_072722243.1 fructose-bisphosphate aldolase class II -
NMK36_RS09545 (NO713_01906) 2269932..2273015 + 3084 WP_254173612.1 N-6 DNA methylase -
NMK36_RS09550 (NO713_01907) 2273217..2273603 - 387 WP_072722242.1 type II toxin-antitoxin system VapC family toxin Toxin
NMK36_RS09555 (NO713_01908) 2273600..2273830 - 231 WP_072722241.1 DUF2281 domain-containing protein Antitoxin
NMK36_RS09560 (NO713_01909) 2274012..2275217 + 1206 WP_072722240.1 sodium/glutamate symporter -
NMK36_RS09565 (NO713_01910) 2275264..2275758 - 495 WP_072722239.1 hypothetical protein -
NMK36_RS09570 (NO713_01911) 2276063..2277496 + 1434 WP_254173613.1 circularly permuted type 2 ATP-grasp protein -
NMK36_RS09575 (NO713_01912) 2277599..2278588 + 990 WP_072722237.1 alpha-E domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(5-127)

Antitoxin

Domain of unknown function DUF2281

(6-74)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14991.42 Da        Isoelectric Point: 4.6643

>T289991 WP_072722242.1 NZ_LR882967:c2273603-2273217 [Planktothrix pseudagardhii]
MNSFLLDTHTFIWLSENDPNLPDSLREMIDIADHVYLSIASLWEIAIKLNLGKLSLQQSYKTIEDKLENSDILLLPIMFI
DTLQICNLPLHHRDPFDRMLIAQAINRSLILISRDIKFDAYPIQRLWD

Download         Length: 387 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8911.16 Da        Isoelectric Point: 4.1813

>AT289991 WP_072722241.1 NZ_LR882967:c2273830-2273600 [Planktothrix pseudagardhii]
MNIDTEILQMVGIMPESLKQELLHYANYLMENYSQKTPSEQPPVKKRRSGILQGTFVLPLSDDFDEPLEDFKEYME

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9BN42

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z9BU65

References