Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3815494..3816179 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID G0TIR9
Locus tag JOA04_RS17730 Protein ID WP_003417998.1
Coordinates 3815769..3816179 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JOA04_RS17725 Protein ID WP_003912220.1
Coordinates 3815494..3815772 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS17705 3811483..3813084 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
JOA04_RS17710 3813101..3813805 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
JOA04_RS17715 3813923..3814489 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
JOA04_RS17720 3814551..3815438 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
JOA04_RS17725 3815494..3815772 + 279 WP_003912220.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JOA04_RS17730 3815769..3816179 + 411 WP_003417998.1 type II toxin-antitoxin system VapC family toxin Toxin
JOA04_RS17735 3816212..3817948 - 1737 WP_003418002.1 cholesterol oxidase -
JOA04_RS17740 3818004..3819131 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
JOA04_RS17745 3819151..3820740 - 1590 WP_003900682.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14695.84 Da        Isoelectric Point: 5.1784

>T289959 WP_003417998.1 NZ_LR882500:3815769-3816179 [Mycobacterium tuberculosis variant microti]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIG
LAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.75 Da        Isoelectric Point: 10.1819

>AT289959 WP_003912220.1 NZ_LR882500:3815494-3815772 [Mycobacterium tuberculosis variant microti]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRT
LSDVLNEMRDEQ

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIR9

Antitoxin

Source ID Structure

References