Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3761214..3761743 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JOA04_RS17490 Protein ID WP_003417760.1
Coordinates 3761486..3761743 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JOA04_RS17485 Protein ID WP_003417757.1
Coordinates 3761214..3761489 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS17465 3758012..3759449 - 1438 Protein_3451 FAD-binding oxidoreductase -
JOA04_RS17470 3759552..3759941 + 390 WP_003417745.1 DUF732 domain-containing protein -
JOA04_RS17475 3759955..3760248 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JOA04_RS17480 3760245..3761090 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JOA04_RS17485 3761214..3761489 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JOA04_RS17490 3761486..3761743 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JOA04_RS17495 3761785..3762975 + 1191 WP_202582083.1 NADH:flavin oxidoreductase -
JOA04_RS17500 3763092..3763460 + 369 WP_003417765.1 FHA domain-containing protein -
JOA04_RS17505 3763457..3764008 - 552 WP_105799777.1 pentapeptide repeat protein MfpA -
JOA04_RS17510 3764015..3764596 - 582 WP_003417769.1 ATP/GTP-binding protein -
JOA04_RS17515 3764577..3764945 - 369 WP_003417772.1 DUF742 domain-containing protein -
JOA04_RS17520 3764923..3765315 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T289957 WP_003417760.1 NZ_LR882500:3761486-3761743 [Mycobacterium tuberculosis variant microti]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT289957 WP_003417757.1 NZ_LR882500:3761214-3761489 [Mycobacterium tuberculosis variant microti]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References