Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3176936..3177484 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag JOA04_RS14930 Protein ID WP_003414602.1
Coordinates 3177221..3177484 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag JOA04_RS14925 Protein ID WP_003414599.1
Coordinates 3176936..3177217 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS14900 3172559..3173416 - 858 WP_003899513.1 type I methionyl aminopeptidase -
JOA04_RS14905 3173458..3174042 - 585 WP_003414585.1 DUF1707 domain-containing protein -
JOA04_RS14910 3174146..3174394 + 249 WP_003913411.1 antitoxin VapB23 -
JOA04_RS14915 3174391..3174771 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
JOA04_RS14920 3174853..3176664 - 1812 WP_003414596.1 penicillin-binding protein -
JOA04_RS14925 3176936..3177217 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
JOA04_RS14930 3177221..3177484 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JOA04_RS14935 3177857..3178711 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JOA04_RS14940 3178767..3179930 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JOA04_RS14945 3179947..3181161 - 1215 WP_003414610.1 zinc metalloprotease Rip -
JOA04_RS14950 3181169..3182410 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T289953 WP_003414602.1 NZ_LR882500:3177221-3177484 [Mycobacterium tuberculosis variant microti]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT289953 WP_003414599.1 NZ_LR882500:3176936-3177217 [Mycobacterium tuberculosis variant microti]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References