Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3073626..3074305 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P9WF90
Locus tag JOA04_RS14370 Protein ID WP_003414059.1
Coordinates 3073626..3074042 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag JOA04_RS14375 Protein ID WP_003414061.1
Coordinates 3074039..3074305 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS14350 3069678..3070580 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
JOA04_RS14355 3070649..3071401 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
JOA04_RS14360 3071645..3071920 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
JOA04_RS14365 3071917..3073539 - 1623 WP_003414057.1 type I restriction-modification system subunit M -
JOA04_RS14370 3073626..3074042 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 Toxin
JOA04_RS14375 3074039..3074305 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JOA04_RS14380 3074331..3074726 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin -
JOA04_RS14385 3074723..3074992 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
JOA04_RS14390 3075002..3076096 - 1095 WP_003414068.1 restriction endonuclease subunit S -
JOA04_RS14395 3076093..3076512 - 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
JOA04_RS14400 3076586..3077065 - 480 WP_003414073.1 dihydrofolate reductase -
JOA04_RS14405 3077136..3077936 - 801 WP_003911953.1 thymidylate synthase -
JOA04_RS14410 3078092..3078829 + 738 WP_003414079.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15773.00 Da        Isoelectric Point: 7.1294

>T289948 WP_003414059.1 NZ_LR882500:c3074042-3073626 [Mycobacterium tuberculosis variant microti]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA

Download         Length: 417 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT289948 WP_003414061.1 NZ_LR882500:c3074305-3074039 [Mycobacterium tuberculosis variant microti]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5SV2

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References