Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2371427..2372122 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag JOA04_RS10900 Protein ID WP_003410811.1
Coordinates 2371427..2371861 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JOA04_RS10905 Protein ID WP_003410814.1
Coordinates 2371868..2372122 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS10890 2367581..2370622 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
JOA04_RS10895 2370615..2371448 + 834 WP_003899172.1 SWIM zinc finger family protein -
JOA04_RS10900 2371427..2371861 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
JOA04_RS10905 2371868..2372122 - 255 WP_003410814.1 antitoxin Antitoxin
JOA04_RS10910 2372138..2372395 - 258 WP_003410816.1 hypothetical protein -
JOA04_RS10915 2373343..2373639 + 297 WP_003410820.1 PE family protein -
JOA04_RS10920 2373695..2374426 + 732 WP_003900467.1 PPE family protein -
JOA04_RS10925 2374966..2375712 - 747 WP_003901330.1 proteasome subunit alpha -
JOA04_RS10930 2375709..2376584 - 876 WP_003411023.1 proteasome subunit beta -
JOA04_RS10935 2376581..2376775 - 195 WP_003411026.1 ubiquitin-like protein Pup -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T289939 WP_003410811.1 NZ_LR882500:c2371861-2371427 [Mycobacterium tuberculosis variant microti]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT289939 WP_003410814.1 NZ_LR882500:c2372122-2371868 [Mycobacterium tuberculosis variant microti]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References