Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2258384..2259010 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag JOA04_RS10410 Protein ID WP_003410075.1
Coordinates 2258612..2259010 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JOA04_RS10405 Protein ID WP_019283586.1
Coordinates 2258384..2258611 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS10395 2256423..2256767 - 345 WP_003410065.1 ferredoxin family protein -
JOA04_RS10400 2256956..2258125 - 1170 WP_003899126.1 ATP-binding protein -
JOA04_RS10405 2258384..2258611 + 228 WP_019283586.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JOA04_RS10410 2258612..2259010 + 399 WP_003410075.1 PIN domain nuclease Toxin
JOA04_RS10415 2259193..2259624 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
JOA04_RS10420 2259725..2260159 + 435 WP_003914358.1 DUF1398 domain-containing protein -
JOA04_RS10425 2260596..2260775 - 180 Protein_2062 hypothetical protein -
JOA04_RS10430 2260836..2261483 + 648 WP_071854215.1 transposase -
JOA04_RS10435 2261437..2262027 + 591 WP_003899131.1 IS110 family transposase -
JOA04_RS10440 2262155..2263411 - 1257 WP_003410095.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T289936 WP_003410075.1 NZ_LR882500:2258612-2259010 [Mycobacterium tuberculosis variant microti]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.14 Da        Isoelectric Point: 4.0995

>AT289936 WP_019283586.1 NZ_LR882500:2258384-2258611 [Mycobacterium tuberculosis variant microti]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSDDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure

References