Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2233078..2233976 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag JOA04_RS10285 Protein ID WP_003410001.1
Coordinates 2233078..2233638 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag JOA04_RS10290 Protein ID WP_003410003.1
Coordinates 2233635..2233976 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS10260 2228761..2229414 - 654 WP_003409976.1 cutinase Cfp21 -
JOA04_RS10265 2229529..2229759 + 231 WP_003409980.1 DUF167 domain-containing protein -
JOA04_RS10270 2229844..2230755 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JOA04_RS10275 2230864..2231463 + 600 WP_003409989.1 L-lysine exporter -
JOA04_RS10280 2231879..2232307 + 429 WP_003409992.1 cellulose-binding protein -
JOA04_RS10285 2233078..2233638 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
JOA04_RS10290 2233635..2233976 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
JOA04_RS10295 2234062..2234319 + 258 WP_003410006.1 hypothetical protein -
JOA04_RS10300 2234220..2234555 - 336 WP_003410009.1 dehydrogenase -
JOA04_RS10305 2234644..2234988 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
JOA04_RS10310 2234982..2235230 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
JOA04_RS10315 2235330..2237645 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JOA04_RS10320 2237642..2237914 - 273 WP_003410017.1 DUF1490 family protein -
JOA04_RS10325 2237967..2238323 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T289934 WP_003410001.1 NZ_LR882500:c2233638-2233078 [Mycobacterium tuberculosis variant microti]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT289934 WP_003410003.1 NZ_LR882500:c2233976-2233635 [Mycobacterium tuberculosis variant microti]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
PDB 6FKG
AlphaFold DB A0A7U4FAE4

References