Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2226266..2226954 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JOA04_RS10245 Protein ID WP_003409958.1
Coordinates 2226266..2226685 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JOA04_RS10250 Protein ID WP_003409968.1
Coordinates 2226694..2226954 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS10220 2221273..2221578 + 306 Protein_2021 ABC transporter permease -
JOA04_RS10225 2221800..2222609 + 810 WP_202582023.1 class I SAM-dependent methyltransferase -
JOA04_RS10230 2222572..2224017 - 1446 WP_202586483.1 APC family permease -
JOA04_RS10235 2224196..2224882 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JOA04_RS10240 2225073..2226041 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JOA04_RS10245 2226266..2226685 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JOA04_RS10250 2226694..2226954 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JOA04_RS10255 2227097..2228773 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JOA04_RS10260 2228761..2229414 - 654 WP_003409976.1 cutinase Cfp21 -
JOA04_RS10265 2229529..2229759 + 231 WP_003409980.1 DUF167 domain-containing protein -
JOA04_RS10270 2229844..2230755 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JOA04_RS10275 2230864..2231463 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T289933 WP_003409958.1 NZ_LR882500:c2226685-2226266 [Mycobacterium tuberculosis variant microti]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT289933 WP_003409968.1 NZ_LR882500:c2226954-2226694 [Mycobacterium tuberculosis variant microti]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References