Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2208216..2208919 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag JOA04_RS10100 Protein ID WP_003409778.1
Coordinates 2208216..2208545 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag JOA04_RS10105 Protein ID WP_003409780.1
Coordinates 2208542..2208919 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS10080 2204600..2205669 + 1070 Protein_1993 epoxide hydrolase EphB -
JOA04_RS10085 2205666..2206181 + 516 WP_003409718.1 flavin reductase family protein -
JOA04_RS10090 2206178..2207239 + 1062 WP_003899092.1 3,4-dihydroxy-2-butanone-4-phosphate synthase -
JOA04_RS10095 2207236..2208006 + 771 WP_003409775.1 SDR family oxidoreductase -
JOA04_RS10100 2208216..2208545 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JOA04_RS10105 2208542..2208919 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
JOA04_RS10110 2208916..2209506 - 591 WP_003409784.1 SEC-C domain-containing protein -
JOA04_RS10115 2209561..2210925 + 1365 WP_003903691.1 HNH endonuclease -
JOA04_RS10120 2211080..2211532 - 453 WP_003899095.1 lipoprotein -
JOA04_RS10125 2211596..2211997 + 402 WP_003409869.1 hypothetical protein -
JOA04_RS10130 2211990..2212172 - 183 WP_003409870.1 hypothetical protein -
JOA04_RS10135 2212286..2212636 - 351 WP_003409871.1 hypothetical protein -
JOA04_RS10140 2212647..2213549 - 903 WP_003409874.1 hypothetical protein -
JOA04_RS10145 2213570..2213761 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T289930 WP_003409778.1 NZ_LR882500:c2208545-2208216 [Mycobacterium tuberculosis variant microti]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT289930 WP_003409780.1 NZ_LR882500:c2208919-2208542 [Mycobacterium tuberculosis variant microti]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References