Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1969868..1970328 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID A0A7U4FB26
Locus tag JOA04_RS09060 Protein ID WP_003408531.1
Coordinates 1970080..1970328 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag JOA04_RS09055 Protein ID WP_003408528.1
Coordinates 1969868..1970080 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS09040 1966346..1967533 - 1188 WP_003898992.1 nitrate transporter NarK -
JOA04_RS09045 1967820..1968104 + 285 WP_003408522.1 DUF1876 domain-containing protein -
JOA04_RS09050 1968118..1969800 - 1683 WP_003898994.1 SulP family inorganic anion transporter -
JOA04_RS09055 1969868..1970080 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JOA04_RS09060 1970080..1970328 + 249 WP_003408531.1 hypothetical protein Toxin
JOA04_RS09065 1970336..1971074 + 739 Protein_1790 hypothetical protein -
JOA04_RS09070 1971168..1972868 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
JOA04_RS09075 1973153..1973554 - 402 WP_003408538.1 hypothetical protein -
JOA04_RS09080 1973544..1974155 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8857.07 Da        Isoelectric Point: 3.9794

>T289929 WP_003408531.1 NZ_LR882500:1970080-1970328 [Mycobacterium tuberculosis variant microti]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYTGDDFACIDIRAVL
AG

Download         Length: 249 bp

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT289929 WP_003408528.1 NZ_LR882500:1969868-1970080 [Mycobacterium tuberculosis variant microti]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB26

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References