Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1949136..1949749 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag JOA04_RS08950 Protein ID WP_003408465.1
Coordinates 1949136..1949525 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag JOA04_RS08955 Protein ID WP_003408469.1
Coordinates 1949522..1949749 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS08920 1944765..1945679 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
JOA04_RS08925 1945682..1946512 + 831 WP_003408448.1 cyclase family protein -
JOA04_RS08930 1946512..1946862 + 351 WP_003898986.1 cupin domain-containing protein -
JOA04_RS08935 1946915..1947733 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
JOA04_RS08940 1947747..1948526 + 780 WP_003408460.1 IclR family transcriptional regulator -
JOA04_RS08950 1949136..1949525 - 390 WP_003408465.1 PIN domain-containing protein Toxin
JOA04_RS08955 1949522..1949749 - 228 WP_003408469.1 antitoxin Antitoxin
JOA04_RS08960 1949967..1951451 + 1485 WP_003408473.1 carboxylase -
JOA04_RS08965 1951448..1952695 + 1248 WP_003408476.1 serine hydrolase -
JOA04_RS08970 1952738..1953157 - 420 WP_105799667.1 hypothetical protein -
JOA04_RS08975 1953147..1953857 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T289928 WP_003408465.1 NZ_LR882500:c1949525-1949136 [Mycobacterium tuberculosis variant microti]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT289928 WP_003408469.1 NZ_LR882500:c1949749-1949522 [Mycobacterium tuberculosis variant microti]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References