Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1775981..1776594 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P64880
Locus tag JOA04_RS08210 Protein ID WP_003407786.1
Coordinates 1776190..1776594 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8UJ46
Locus tag JOA04_RS08205 Protein ID WP_009935474.1
Coordinates 1775981..1776184 (+) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS08190 1771245..1774148 + 2904 WP_202582014.1 MMPL family transporter -
JOA04_RS08195 1774158..1774604 + 447 WP_003407780.1 F420H(2)-dependent quinone reductase -
JOA04_RS08200 1774639..1775928 + 1290 WP_003407781.1 threonine ammonia-lyase -
JOA04_RS08205 1775981..1776184 + 204 WP_009935474.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JOA04_RS08210 1776190..1776594 + 405 WP_003407786.1 type II toxin-antitoxin system toxin ribonuclease VapC11 Toxin
JOA04_RS08215 1776611..1778353 - 1743 WP_003407788.1 malto-oligosyltrehalose trehalohydrolase -
JOA04_RS08220 1778346..1780643 - 2298 WP_105799702.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14650.76 Da        Isoelectric Point: 5.6587

>T289927 WP_003407786.1 NZ_LR882500:1776190-1776594 [Mycobacterium tuberculosis variant microti]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Download         Length: 405 bp

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7501.48 Da        Isoelectric Point: 4.3951

>AT289927 WP_009935474.1 NZ_LR882500:1775981-1776184 [Mycobacterium tuberculosis variant microti]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Download         Length: 204 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6A7V

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8UJ46

References