Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1548217..1549267 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag JOA04_RS07195 Protein ID WP_003407164.1
Coordinates 1548217..1549038 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag JOA04_RS07200 Protein ID WP_003407167.1
Coordinates 1549031..1549267 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS07175 1543766..1544428 - 663 WP_003407152.1 membrane protein -
JOA04_RS07180 1544425..1545219 - 795 WP_031703329.1 hypothetical protein -
JOA04_RS07185 1545510..1547471 - 1962 WP_202582006.1 SpoIIE family protein phosphatase -
JOA04_RS07190 1547610..1547996 - 387 WP_003407162.1 anti-sigma-F factor antagonist RsfA -
JOA04_RS07195 1548217..1549038 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
JOA04_RS07200 1549031..1549267 + 237 WP_003407167.1 hypothetical protein Antitoxin
JOA04_RS07205 1549339..1550544 - 1206 WP_003918234.1 serine hydrolase -
JOA04_RS07210 1550847..1551632 + 786 WP_003407180.1 lipoprotein LprF -
JOA04_RS07215 1551828..1553297 + 1470 WP_105799839.1 fatty acid desaturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T289924 WP_003407164.1 NZ_LR882500:1548217-1549038 [Mycobacterium tuberculosis variant microti]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT289924 WP_003407167.1 NZ_LR882500:1549031-1549267 [Mycobacterium tuberculosis variant microti]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References