Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1392379..1392938 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag JOA04_RS06530 Protein ID WP_003898789.1
Coordinates 1392379..1392672 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag JOA04_RS06535 Protein ID WP_003406322.1
Coordinates 1392669..1392938 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS06505 1387973..1388233 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
JOA04_RS06510 1388230..1388661 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
JOA04_RS06515 1388684..1390371 - 1688 Protein_1284 PE family protein -
JOA04_RS06520 1390551..1391411 + 861 WP_003406306.1 hypothetical protein -
JOA04_RS06525 1391492..1392322 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
JOA04_RS06530 1392379..1392672 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
JOA04_RS06535 1392669..1392938 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JOA04_RS06540 1393051..1396746 - 3696 WP_003406323.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
JOA04_RS06545 1396888..1397676 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T289923 WP_003898789.1 NZ_LR882500:c1392672-1392379 [Mycobacterium tuberculosis variant microti]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT289923 WP_003406322.1 NZ_LR882500:c1392938-1392669 [Mycobacterium tuberculosis variant microti]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References