Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1387973..1388661 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID G0THR7
Locus tag JOA04_RS06510 Protein ID WP_003406304.1
Coordinates 1388230..1388661 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0THR6
Locus tag JOA04_RS06505 Protein ID WP_003406302.1
Coordinates 1387973..1388233 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS06485 1383550..1384374 + 825 WP_003900298.1 trehalose ABC transporter permease SugB -
JOA04_RS06490 1384379..1385560 + 1182 WP_003406299.1 trehalose ABC transporter ATP-binding protein SugC -
JOA04_RS06495 1385637..1386737 - 1101 WP_003406300.1 magnesium/cobalt transporter CorA -
JOA04_RS06500 1386908..1387897 + 990 WP_003406301.1 malate dehydrogenase -
JOA04_RS06505 1387973..1388233 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 Antitoxin
JOA04_RS06510 1388230..1388661 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin Toxin
JOA04_RS06515 1388684..1390371 - 1688 Protein_1284 PE family protein -
JOA04_RS06520 1390551..1391411 + 861 WP_003406306.1 hypothetical protein -
JOA04_RS06525 1391492..1392322 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
JOA04_RS06530 1392379..1392672 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE -
JOA04_RS06535 1392669..1392938 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15873.08 Da        Isoelectric Point: 5.8838

>T289922 WP_003406304.1 NZ_LR882500:1388230-1388661 [Mycobacterium tuberculosis variant microti]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Download         Length: 432 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9918.25 Da        Isoelectric Point: 6.4755

>AT289922 WP_003406302.1 NZ_LR882500:1387973-1388233 [Mycobacterium tuberculosis variant microti]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THR7

Antitoxin

Source ID Structure
AlphaFold DB G0THR6

References