Detailed information of TA system TA028992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 2098599..2099143
• Replicon: chromosome
• Accession: NC_020516
• Organism: Azoarcus sp. KH32C

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: AZKH_RS09240
• Protein ID: WP_041656042.1
• Coordinates: 2098868..2099143 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H0PTM2
• Locus tag: AZKH_RS09235
• Protein ID: WP_015435492.1
• Coordinates: 2098599..2098868 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZKH_RS09225	2094248..2096467	+	2220	WP_015435490.1	indolepyruvate ferredoxin oxidoreductase subunit alpha	-
AZKH_RS09230	2096482..2098041	+	1560	Protein_1818	indolepyruvate oxidoreductase subunit beta family protein	-
AZKH_RS09235	2098599..2098868	+	270	WP_015435492.1	ribbon-helix-helix domain-containing protein	Antitoxin
AZKH_RS09240	2098868..2099143	+	276	WP_041656042.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
AZKH_RS09245	2100336..2101760	-	1425	WP_015435493.1	aldehyde dehydrogenase family protein	-
AZKH_RS09250	2101907..2102869	-	963	WP_156822210.1	glycosyl hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-46)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10699.36 Da
• Isoelectric Point: 8.4941

>T28992 WP_041656042.1 NC_020516:2098868-2099143 [Azoarcus sp. KH32C]
MELKWTGKALSDLARLYEFLAPVNKPAAARTIQALTAAPSSLLVNPRIGERLDEFEPREVRRILVGHYEMRYEIQESTIY
MLRLWHTREDR

Nucleotide

• Length: 276 bp

>T28992 NC_020516:2098868-2099143 [Azoarcus sp. KH32C]
ATGGAGCTGAAGTGGACCGGCAAGGCGCTCTCCGACTTGGCTCGTCTGTACGAATTTCTCGCCCCGGTGAATAAGCCTGC
CGCTGCACGTACGATACAGGCGCTCACGGCTGCGCCGTCAAGTTTGCTGGTGAACCCGCGCATCGGCGAACGGCTCGATG
AATTCGAGCCGCGCGAGGTGCGGCGGATTCTCGTGGGGCATTACGAGATGCGCTACGAGATTCAGGAATCGACGATCTAC
ATGCTGAGGCTGTGGCACACCCGAGAGGATCGCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9944.30 Da
• Isoelectric Point: 5.1007

>AT28992 WP_015435492.1 NC_020516:2098599-2098868 [Azoarcus sp. KH32C]
MAQTETKVLTAHVPLPLAEKVDQMAARLERSRGWIMKQALSAWIDQEEERSRLTREALADVDAGRVIDHQAVQAWADSLG
TDTPLPVPR

Nucleotide

• Length: 270 bp

>AT28992 NC_020516:2098599-2098868 [Azoarcus sp. KH32C]
ATGGCACAGACCGAAACCAAAGTGCTGACCGCACATGTCCCCCTTCCGTTGGCGGAAAAAGTCGATCAGATGGCTGCCCG
ACTTGAACGATCGCGGGGCTGGATCATGAAGCAGGCGCTGTCGGCCTGGATCGACCAGGAGGAAGAGCGCAGCCGCCTGA
CCCGCGAGGCGCTTGCCGACGTGGACGCCGGTCGGGTCATCGACCATCAGGCCGTGCAGGCCTGGGCCGACAGTCTCGGT
ACCGACACGCCATTGCCGGTGCCGCGCTGA

Structures

Antitoxin

• AlphaFold DB: H0PTM2