Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 1025725..1026698 | Replicon | chromosome |
Accession | NZ_LR882500 | ||
Organism | Mycobacterium tuberculosis variant microti strain 94-2272 isolate human |
Toxin (Protein)
Gene name | tacT | Uniprot ID | O05911 |
Locus tag | JOA04_RS04830 | Protein ID | WP_003404756.1 |
Coordinates | 1026198..1026698 (+) | Length | 167 a.a. |
Antitoxin (Protein)
Gene name | tacA | Uniprot ID | G0TFR4 |
Locus tag | JOA04_RS04825 | Protein ID | WP_003404754.1 |
Coordinates | 1025725..1026201 (+) | Length | 159 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JOA04_RS04805 | 1021572..1022843 | - | 1272 | WP_003404747.1 | PPE family protein | - |
JOA04_RS04810 | 1022858..1023157 | - | 300 | WP_003404748.1 | PE family protein | - |
JOA04_RS04815 | 1023601..1025382 | + | 1782 | WP_003404749.1 | BCCT family transporter | - |
JOA04_RS04820 | 1025379..1025636 | + | 258 | WP_003404750.1 | hypothetical protein | - |
JOA04_RS04825 | 1025725..1026201 | + | 477 | WP_003404754.1 | DUF1778 domain-containing protein | Antitoxin |
JOA04_RS04830 | 1026198..1026698 | + | 501 | WP_003404756.1 | GNAT family N-acetyltransferase | Toxin |
JOA04_RS04840 | 1027011..1028330 | - | 1320 | WP_003404757.1 | IS256-like element IS1554 family transposase | - |
JOA04_RS04845 | 1028618..1029199 | + | 582 | WP_105799544.1 | IS607-like element IS1535 family transposase | - |
JOA04_RS04850 | 1029199..1030857 | + | 1659 | WP_105799545.1 | IS607 family element transposase accessory protein TnpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 1025379..1077072 | 51693 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18048.55 Da Isoelectric Point: 7.8659
>T289918 WP_003404756.1 NZ_LR882500:1026198-1026698 [Mycobacterium tuberculosis variant microti]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD
Download Length: 501 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 17357.95 Da Isoelectric Point: 11.2467
>AT289918 WP_003404754.1 NZ_LR882500:1025725-1026201 [Mycobacterium tuberculosis variant microti]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSZ2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TFR4 |