Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1025725..1026698 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag JOA04_RS04830 Protein ID WP_003404756.1
Coordinates 1026198..1026698 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID G0TFR4
Locus tag JOA04_RS04825 Protein ID WP_003404754.1
Coordinates 1025725..1026201 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS04805 1021572..1022843 - 1272 WP_003404747.1 PPE family protein -
JOA04_RS04810 1022858..1023157 - 300 WP_003404748.1 PE family protein -
JOA04_RS04815 1023601..1025382 + 1782 WP_003404749.1 BCCT family transporter -
JOA04_RS04820 1025379..1025636 + 258 WP_003404750.1 hypothetical protein -
JOA04_RS04825 1025725..1026201 + 477 WP_003404754.1 DUF1778 domain-containing protein Antitoxin
JOA04_RS04830 1026198..1026698 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
JOA04_RS04840 1027011..1028330 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
JOA04_RS04845 1028618..1029199 + 582 WP_105799544.1 IS607-like element IS1535 family transposase -
JOA04_RS04850 1029199..1030857 + 1659 WP_105799545.1 IS607 family element transposase accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1025379..1077072 51693


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T289918 WP_003404756.1 NZ_LR882500:1026198-1026698 [Mycobacterium tuberculosis variant microti]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17357.95 Da        Isoelectric Point: 11.2467

>AT289918 WP_003404754.1 NZ_LR882500:1025725-1026201 [Mycobacterium tuberculosis variant microti]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB G0TFR4

References