Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 712301..712926 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag JOA04_RS03225 Protein ID WP_003403218.1
Coordinates 712525..712926 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JOA04_RS03220 Protein ID WP_105799908.1
Coordinates 712301..712528 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS03195 707471..707692 - 222 WP_003898525.1 DUF4926 domain-containing protein -
JOA04_RS03200 707834..708439 + 606 WP_105799909.1 hypothetical protein -
JOA04_RS03205 708458..711025 - 2568 WP_003900188.1 SEC-C domain-containing protein -
JOA04_RS03210 711109..711867 + 759 WP_202581976.1 hypothetical protein -
JOA04_RS03215 711864..712106 + 243 WP_003403210.1 hypothetical protein -
JOA04_RS03220 712301..712528 + 228 WP_105799908.1 antitoxin Antitoxin
JOA04_RS03225 712525..712926 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
JOA04_RS03230 713055..713138 + 84 Protein_639 galactose-1-phosphate uridylyltransferase -
JOA04_RS03235 713157..714239 + 1083 WP_031652152.1 galactose-1-phosphate uridylyltransferase -
JOA04_RS03240 714236..715327 + 1092 WP_003403225.1 galactokinase -
JOA04_RS03245 715722..716879 + 1158 WP_003903091.1 hypothetical protein -
JOA04_RS03250 716890..717837 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T289909 WP_003403218.1 NZ_LR882500:712525-712926 [Mycobacterium tuberculosis variant microti]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8191.23 Da        Isoelectric Point: 5.6307

>AT289909 WP_105799908.1 NZ_LR882500:712301-712528 [Mycobacterium tuberculosis variant microti]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLVANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure

References