Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 445517..446528 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag JOA04_RS01915 Protein ID WP_003401859.1
Coordinates 445517..446110 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag JOA04_RS01920 Protein ID WP_003401860.1
Coordinates 446139..446528 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS01895 441166..442548 + 1383 WP_105799635.1 magnesium transporter -
JOA04_RS01900 442560..443594 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
JOA04_RS01905 443690..444373 + 684 WP_003401857.1 VTT domain-containing protein -
JOA04_RS01910 444362..445492 - 1131 WP_003401858.1 hypothetical protein -
JOA04_RS01915 445517..446110 - 594 WP_003401859.1 zeta toxin family protein Toxin
JOA04_RS01920 446139..446528 - 390 WP_003401860.1 hypothetical protein Antitoxin
JOA04_RS01925 446609..447820 - 1212 WP_105799636.1 VWA domain-containing protein -
JOA04_RS01930 447826..448428 - 603 WP_003898417.1 SRPBCC family protein -
JOA04_RS01935 448442..449338 - 897 WP_003401863.1 MoxR family ATPase -
JOA04_RS01940 449335..449928 - 594 WP_003401864.1 NTP transferase domain-containing protein -
JOA04_RS01945 449925..450680 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T289904 WP_003401859.1 NZ_LR882500:c446110-445517 [Mycobacterium tuberculosis variant microti]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT289904 WP_003401860.1 NZ_LR882500:c446528-446139 [Mycobacterium tuberculosis variant microti]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References