Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 71680..72313 Replicon chromosome
Accession NZ_LR882500
Organism Mycobacterium tuberculosis variant microti strain 94-2272 isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag JOA04_RS00360 Protein ID WP_003400580.1
Coordinates 71912..72313 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P0CW29
Locus tag JOA04_RS00355 Protein ID WP_003400577.1
Coordinates 71680..71919 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JOA04_RS00340 66977..68416 + 1440 WP_105799815.1 FAD-binding oxidoreductase -
JOA04_RS00345 68472..68633 + 162 WP_003899796.1 hypothetical protein -
JOA04_RS00350 68674..71613 + 2940 Protein_65 UPF0182 family protein -
JOA04_RS00355 71680..71919 + 240 WP_003400577.1 antitoxin VapB1 Antitoxin
JOA04_RS00360 71912..72313 + 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
JOA04_RS00365 72365..74602 - 2238 WP_003400583.1 NADP-dependent isocitrate dehydrogenase -
JOA04_RS00370 74720..75289 - 570 WP_003400591.1 TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator -
JOA04_RS00375 75392..76303 + 912 WP_003899798.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T289900 WP_003400580.1 NZ_LR882500:71912-72313 [Mycobacterium tuberculosis variant microti]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 8.5960

>AT289900 WP_003400577.1 NZ_LR882500:71680-71919 [Mycobacterium tuberculosis variant microti]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHM7

References