Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3749297..3749826 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JN986_RS17415 Protein ID WP_003417760.1
Coordinates 3749569..3749826 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JN986_RS17410 Protein ID WP_003417757.1
Coordinates 3749297..3749572 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS17390 3746095..3747532 - 1438 Protein_3434 FAD-binding oxidoreductase -
JN986_RS17395 3747635..3748024 + 390 WP_003417745.1 DUF732 domain-containing protein -
JN986_RS17400 3748038..3748331 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JN986_RS17405 3748328..3749173 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JN986_RS17410 3749297..3749572 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JN986_RS17415 3749569..3749826 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JN986_RS17420 3749868..3751058 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
JN986_RS17425 3751175..3751543 + 369 WP_003417765.1 FHA domain-containing protein -
JN986_RS17430 3751540..3752091 - 552 WP_105799777.1 pentapeptide repeat protein MfpA -
JN986_RS17435 3752098..3752679 - 582 WP_003417769.1 ATP/GTP-binding protein -
JN986_RS17440 3752660..3753028 - 369 WP_003417772.1 DUF742 domain-containing protein -
JN986_RS17445 3753006..3753398 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T289897 WP_003417760.1 NZ_LR882499:3749569-3749826 [Mycobacterium tuberculosis variant microti OV254]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT289897 WP_003417757.1 NZ_LR882499:3749297-3749572 [Mycobacterium tuberculosis variant microti OV254]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References