Detailed information of TA system TA028989

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1810209..1811743
• Replicon: chromosome
• Accession: NC_020515
• Organism: Bibersteinia trehalosi USDA-ARS-USMARC-192

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A4V7I8D4
• Locus tag: WQG_RS08200
• Protein ID: WP_015433059.1
• Coordinates: 1810209..1811495 (-)
• Length: 429 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: WQG_RS08205
• Protein ID: WP_015433060.1
• Coordinates: 1811489..1811743 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
WQG_RS08170	1805228..1806376	+	1149	WP_015433053.1	TIR domain-containing protein	-
WQG_RS08175	1806442..1807116	-	675	WP_038445703.1	stress protein	-
WQG_RS08180	1807164..1807739	-	576	WP_015433055.1	TerD family protein	-
WQG_RS08185	1807779..1808558	-	780	WP_015433056.1	hypothetical protein	-
WQG_RS08190	1808559..1809560	-	1002	WP_015433057.1	TerC/Alx family metal homeostasis membrane protein	-
WQG_RS08195	1809709..1810137	+	429	WP_015433058.1	helix-turn-helix domain-containing protein	-
WQG_RS08200	1810209..1811495	-	1287	WP_015433059.1	type II toxin-antitoxin system HipA family toxin	Toxin
WQG_RS08205	1811489..1811743	-	255	WP_015433060.1	helix-turn-helix domain-containing protein	Antitoxin
WQG_RS11425	1811859..1812044	-	186	Protein_1585	ATP-binding protein	-
WQG_RS08210	1812182..1812586	-	405	Protein_1586	ABC transporter ATP-binding protein	-
WQG_RS08215	1812845..1814158	+	1314	WP_015433063.1	MFS transporter	-
WQG_RS08220	1814392..1814844	+	453	WP_025266848.1	hypothetical protein	-
WQG_RS08225	1814848..1815477	+	630	WP_015433065.1	DsbA family oxidoreductase	-
WQG_RS08230	1815470..1816051	+	582	WP_015433066.1	rhomboid family intramembrane serine protease	-
WQG_RS08235	1816102..1816743	-	642	WP_015433067.1	orotate phosphoribosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (148-394)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 429 a.a.
• Molecular weight: 48546.92 Da
• Isoelectric Point: 7.9839

>T28989 WP_015433059.1 NC_020515:c1811495-1810209 [Bibersteinia trehalosi USDA-ARS-USMARC-192]
MVGNVLTVAMNGLEVGHWQKLSSGATEFCYIPSWLNSPRKRAISLSLPLSDQIYRGDVVYNFFDNLLPDNELIRSRIQQR
FQTTTKSPFDLLSAIGQDCVGAIQLYNQTPSPTQNINAQKLVDQEIEHILQNYQSLPLGMAEQADFRISIAGAQEKTAFL
YHQGEWKRPLGSTPTTHIFKLPIGVVGQGQIDLSNSCENEWLCLNILRVFGLPVSQAEIAYFGETKVLIIERFDRRWAKD
NSYLLRLPQEDMCQAFNIAPARKYENDGGVGILPIMQLLKGSSNALADQKAFFKAQILFWLLCAIDGHAKNFSLFLEPNN
RYKLTPFYDVISAYPLISPKGLQKQKVKMAMAWHGEQNKHYLWDKIQLRHIFNTAKLAGLSKQTVEEILQEIVVASSRLN
SIPTQHLPEQIVDPILSEMERKLVVVNR

Nucleotide

• Length: 1287 bp

>T28989 NC_020515:c1811495-1810209 [Bibersteinia trehalosi USDA-ARS-USMARC-192]
ATGGTAGGCAATGTACTGACGGTTGCGATGAATGGGTTAGAAGTTGGGCATTGGCAAAAACTTTCTAGCGGAGCAACGGA
ATTTTGTTATATCCCGAGCTGGCTCAACTCTCCACGAAAACGAGCGATTTCTCTTTCATTACCGCTATCGGATCAAATTT
ATCGTGGTGATGTAGTCTATAATTTTTTCGATAATTTGTTGCCGGACAATGAATTAATTCGCTCCCGTATTCAGCAACGT
TTTCAAACCACCACAAAATCGCCGTTCGATTTGCTTTCGGCAATCGGGCAAGACTGTGTGGGAGCTATTCAGCTTTATAA
TCAAACACCTTCGCCCACTCAGAACATTAACGCTCAAAAGCTGGTAGATCAGGAAATTGAGCATATTTTACAAAATTATC
AAAGCCTGCCACTGGGTATGGCGGAGCAGGCAGATTTCCGTATTTCAATTGCTGGTGCGCAGGAAAAAACGGCCTTTCTT
TACCATCAAGGCGAATGGAAACGCCCGTTGGGTTCAACGCCAACCACACATATTTTCAAATTACCGATCGGTGTTGTTGG
ACAAGGGCAAATCGACCTTTCGAATAGTTGTGAAAATGAGTGGCTCTGTTTGAATATTTTGCGGGTATTTGGCTTGCCTG
TATCTCAGGCGGAAATTGCCTATTTTGGTGAAACCAAAGTGCTGATTATCGAACGTTTTGACCGCCGTTGGGCGAAGGAC
AATAGCTATTTGCTCCGTTTACCACAAGAAGATATGTGCCAAGCGTTTAACATTGCTCCGGCTCGGAAATATGAAAATGA
TGGTGGCGTTGGTATTCTGCCAATTATGCAACTCCTCAAAGGTTCGAGCAATGCACTTGCCGATCAAAAAGCCTTTTTCA
AAGCCCAAATTCTGTTTTGGCTGCTCTGTGCAATTGACGGACACGCCAAAAATTTCAGCCTATTTTTAGAACCTAACAAC
CGCTATAAACTTACGCCGTTTTACGATGTGATTTCCGCCTACCCATTGATTAGCCCGAAAGGCTTGCAAAAACAGAAAGT
TAAAATGGCAATGGCGTGGCACGGCGAGCAGAATAAGCACTATCTTTGGGATAAAATCCAACTTCGACATATTTTTAATA
CTGCAAAGTTAGCAGGCTTATCAAAACAGACAGTGGAGGAAATATTACAGGAGATTGTTGTGGCTTCATCACGATTAAAT
AGTATCCCGACACAACATTTGCCCGAACAAATTGTTGACCCGATTTTGAGTGAGATGGAGAGAAAGTTGGTTGTGGTGAA
TAGGTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9528.92 Da
• Isoelectric Point: 4.7661

>AT28989 WP_015433060.1 NC_020515:c1811743-1811489 [Bibersteinia trehalosi USDA-ARS-USMARC-192]
MVATTPQMLAHAVKEYRNLQKKSQTEVATVANTKQSTISIFENDPTGTKIETLFNILMALELELVVQPRPKSRDILQDEE
GEIW

Nucleotide

• Length: 255 bp

>AT28989 NC_020515:c1811743-1811489 [Bibersteinia trehalosi USDA-ARS-USMARC-192]
ATGGTTGCTACCACGCCACAAATGTTGGCACACGCAGTGAAAGAATACCGTAACTTACAGAAAAAATCGCAAACTGAAGT
TGCCACAGTTGCTAACACTAAGCAATCGACGATCTCCATATTTGAAAATGATCCCACTGGCACAAAAATTGAAACTTTGT
TCAATATTTTAATGGCATTAGAATTAGAGTTAGTCGTCCAGCCTCGCCCGAAAAGTCGTGATATTTTGCAAGATGAAGAG
GGCGAGATATGGTAG

Structures

Toxin

• AlphaFold DB: A0A4V7I8D4