289889

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3065262..3065949 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID G0TF65
Locus tag JN986_RS14330 Protein ID WP_003414064.1
Coordinates 3065554..3065949 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TF64
Locus tag JN986_RS14325 Protein ID WP_003414061.1
Coordinates 3065262..3065528 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS14300 3060901..3061803 - 903 WP_003900564.1 4-hydroxy-tetrahydrodipicolinate synthase -
JN986_RS14305 3061872..3062624 - 753 WP_003899465.1 FAD-dependent thymidylate synthase -
JN986_RS14310 3062868..3063143 - 276 WP_003414055.1 type I restriction endonuclease subunit S -
JN986_RS14315 3063140..3064762 - 1623 WP_003414057.1 type I restriction-modification system subunit M -
JN986_RS14320 3064849..3065265 - 417 WP_003414059.1 type II toxin-antitoxin system toxin ribonuclease C21 -
JN986_RS14325 3065262..3065528 - 267 WP_003414061.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN986_RS14330 3065554..3065949 - 396 WP_003414064.1 type II toxin-antitoxin system VapC family toxin Toxin
JN986_RS14335 3065946..3066215 - 270 WP_003414066.1 type II toxin-antitoxin system VapB family antitoxin -
JN986_RS14340 3066225..3067319 - 1095 WP_003414068.1 restriction endonuclease subunit S -
JN986_RS14345 3067316..3067735 - 420 WP_003414070.1 winged helix-turn-helix domain-containing protein -
JN986_RS14350 3067809..3068288 - 480 WP_003414073.1 dihydrofolate reductase -
JN986_RS14355 3068359..3069159 - 801 WP_003911953.1 thymidylate synthase -
JN986_RS14360 3069315..3070052 + 738 WP_003414079.1 dienelactone hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(16-56)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14340.04 Da        Isoelectric Point: 4.7145

>T289889 WP_003414064.1 NZ_LR882499:c3065949-3065554 [Mycobacterium tuberculosis variant microti OV254]
VIVDTSAIVAIVSGESGAQVLKEALERSPNSRMSAPNYVELCAIMQRRDRPEISRLVDRLLDDYGIQVEAVDADQARVAA
QAYRDYGRGSGHPARLNLGDTYSYALAQVTGEPLLFRGDDFTHTDIRPACT

Download         Length: 396 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9493.77 Da        Isoelectric Point: 7.2783

>AT289889 WP_003414061.1 NZ_LR882499:c3065528-3065262 [Mycobacterium tuberculosis variant microti OV254]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TF65

Antitoxin

Source ID Structure
AlphaFold DB G0TF64

References