Detailed information of TA system TA028988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 3164437..3164861
• Replicon: chromosome
• Accession: NC_020514
• Organism: Glaciecola psychrophila 170

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: C427_RS13800
• Protein ID: WP_007638680.1
• Coordinates: 3164437..3164691 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: K7AS31
• Locus tag: C427_RS13805
• Protein ID: WP_007638681.1
• Coordinates: 3164691..3164861 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C427_RS13785	3161267..3161761	+	495	WP_007638678.1	hypothetical protein	-
C427_RS13790	3161743..3162867	+	1125	WP_007638679.1	hypothetical protein	-
C427_RS25000	3163325..3164204	-	880	Protein_2775	transposase	-
C427_RS13800	3164437..3164691	-	255	WP_007638680.1	hypothetical protein	Toxin
C427_RS13805	3164691..3164861	-	171	WP_007638681.1	hypothetical protein	Antitoxin
C427_RS13815	3165291..3166007	+	717	WP_148285913.1	hypothetical protein	-
C427_RS13820	3166097..3166336	+	240	WP_007638684.1	LysM peptidoglycan-binding domain-containing protein	-
C427_RS13825	3166353..3167111	-	759	WP_007638686.1	tRNA-(ms[2]io[6]A)-hydroxylase	-
C427_RS13830	3167264..3167548	-	285	WP_148285914.1	helix-turn-helix domain-containing protein	-
C427_RS13835	3167541..3167768	-	228	WP_081589020.1	type II toxin-antitoxin system RelE/ParE family toxin	-
C427_RS25005	3167953..3168087	-	135	Protein_2783	tRNA-(ms[2]io[6]A)-hydroxylase	-
C427_RS25010	3168635..3168870	-	236	Protein_2784	type II toxin-antitoxin system ParD family antitoxin	-
C427_RS13840	3169171..3169434	-	264	WP_007638693.1	type II toxin-antitoxin system CcdA family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (2-62)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9233.51 Da
• Isoelectric Point: 4.0334

>T28988 WP_007638680.1 NC_020514:c3164691-3164437 [Paraglaciecola psychrophila 170]
VEIICFPFETVVEINIFILEGEPDMKGTVDVPKLQGALGRIDHALVYDGLDDIFEIAAKYFQENSSILSPKYKPLVSNDG
ASST

Nucleotide

• Length: 255 bp

>T28988 NC_020514:c3164691-3164437 [Paraglaciecola psychrophila 170]
GTGGAAATAATTTGTTTCCCCTTTGAAACAGTTGTTGAAATTAACATTTTTATTTTAGAAGGTGAGCCTGATATGAAAGG
AACAGTTGATGTTCCAAAGTTACAAGGTGCGTTAGGCCGTATTGATCATGCATTAGTTTATGATGGTTTAGATGATATTT
TCGAAATTGCTGCCAAATACTTTCAAGAGAACTCATCTATTTTAAGTCCCAAATACAAACCACTTGTGTCGAATGATGGG
GCAAGCTCAACCTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6389.38 Da
• Isoelectric Point: 10.5393

>AT28988 WP_007638681.1 NC_020514:c3164861-3164691 [Paraglaciecola psychrophila 170]
MNKKVEDYGVRAVNRPKVKATKVLDLSGDTGEQIVRSETKLALRTHNKTFEIRAYI

Nucleotide

• Length: 171 bp

>AT28988 NC_020514:c3164861-3164691 [Paraglaciecola psychrophila 170]
ATGAATAAAAAAGTTGAAGATTACGGCGTTAGAGCGGTAAATAGACCCAAAGTTAAAGCAACCAAAGTGCTTGATTTATC
TGGAGATACAGGTGAGCAAATTGTACGGTCTGAAACTAAGTTGGCTTTAAGAACACACAATAAAACATTTGAAATACGGG
CTTATATATAG

Structures

Antitoxin

• AlphaFold DB: K7AS31