289876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2258632..2259258 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID P64926
Locus tag JN986_RS10400 Protein ID WP_003410075.1
Coordinates 2258860..2259258 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JN986_RS10395 Protein ID WP_019283586.1
Coordinates 2258632..2258859 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS10385 2256671..2257015 - 345 WP_003410065.1 ferredoxin family protein -
JN986_RS10390 2257204..2258373 - 1170 WP_003899126.1 ATP-binding protein -
JN986_RS10395 2258632..2258859 + 228 WP_019283586.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN986_RS10400 2258860..2259258 + 399 WP_003410075.1 PIN domain nuclease Toxin
JN986_RS10405 2259441..2259872 - 432 WP_003410078.1 MarR family winged helix-turn-helix transcriptional regulator -
JN986_RS10410 2259973..2260407 + 435 WP_003914358.1 DUF1398 domain-containing protein -
JN986_RS10415 2260844..2261023 - 180 Protein_2058 hypothetical protein -
JN986_RS10420 2261084..2261731 + 648 WP_071854215.1 transposase -
JN986_RS10425 2261685..2262275 + 591 WP_003899131.1 IS110 family transposase -
JN986_RS10430 2262403..2263659 - 1257 WP_003410095.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14731.02 Da        Isoelectric Point: 6.7067

>T289876 WP_003410075.1 NZ_LR882499:2258860-2259258 [Mycobacterium tuberculosis variant microti OV254]
MIVDTSVWIAYLSTSESLASRWLADRIAADSTVIVPEVVMMELLIGKTDEDTAALRRRLLQRFAIEPLAPVRDAEDAAAI
HRRCRRGGDTVRSLIDCQVAAMALRIGVAVAHRDRDYEAIRTHCGLRTEPLF

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8347.14 Da        Isoelectric Point: 4.0995

>AT289876 WP_019283586.1 NZ_LR882499:2258632-2258859 [Mycobacterium tuberculosis variant microti OV254]
VSRTNIEIDDELVAAAQRMYRLDSKRSAVDLALRRLVGEPLGRDEALALQGSGFDFSDDEIESFSDTDRKLADES

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4CHG

Antitoxin

Source ID Structure

References