Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2226000..2226688 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN986_RS10230 Protein ID WP_003409958.1
Coordinates 2226000..2226419 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN986_RS10235 Protein ID WP_003409968.1
Coordinates 2226428..2226688 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS10210 2221792..2222343 + 552 Protein_2017 class I SAM-dependent methyltransferase -
JN986_RS10215 2222306..2223751 - 1446 WP_202592787.1 APC family permease -
JN986_RS10220 2223930..2224616 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JN986_RS10225 2224807..2225775 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN986_RS10230 2226000..2226419 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN986_RS10235 2226428..2226688 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN986_RS10240 2226831..2228507 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JN986_RS10245 2228495..2229148 - 654 WP_003409976.1 cutinase Cfp21 -
JN986_RS10250 2229263..2229493 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN986_RS10255 2229578..2230489 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN986_RS10260 2230598..2231197 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T289873 WP_003409958.1 NZ_LR882499:c2226419-2226000 [Mycobacterium tuberculosis variant microti OV254]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT289873 WP_003409968.1 NZ_LR882499:c2226688-2226428 [Mycobacterium tuberculosis variant microti OV254]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References