289870

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2206590..2207293 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name mazF Uniprot ID G0TLK7
Locus tag JN986_RS10075 Protein ID WP_003409778.1
Coordinates 2206590..2206919 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TLK8
Locus tag JN986_RS10080 Protein ID WP_003409780.1
Coordinates 2206916..2207293 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS10055 2202976..2204042 + 1067 Protein_1986 epoxide hydrolase EphB -
JN986_RS10060 2204039..2204554 + 516 WP_202592786.1 flavin reductase family protein -
JN986_RS10065 2204551..2205613 + 1063 Protein_1988 3,4-dihydroxy-2-butanone-4-phosphate synthase -
JN986_RS10070 2205610..2206380 + 771 WP_003409775.1 SDR family oxidoreductase -
JN986_RS10075 2206590..2206919 - 330 WP_003409778.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JN986_RS10080 2206916..2207293 - 378 WP_003409780.1 type II toxin-antitoxin system antitoxin MazE5 Antitoxin
JN986_RS10085 2207290..2207880 - 591 WP_003409784.1 SEC-C domain-containing protein -
JN986_RS10090 2207935..2209299 + 1365 WP_003903691.1 HNH endonuclease -
JN986_RS10095 2209454..2209906 - 453 WP_003899095.1 lipoprotein -
JN986_RS10100 2209970..2210371 + 402 WP_003409869.1 hypothetical protein -
JN986_RS10105 2210364..2210546 - 183 WP_003409870.1 hypothetical protein -
JN986_RS10110 2210660..2211010 - 351 WP_003409871.1 hypothetical protein -
JN986_RS10115 2211021..2211923 - 903 WP_003409874.1 hypothetical protein -
JN986_RS10120 2211944..2212135 - 192 WP_003409876.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11787.82 Da        Isoelectric Point: 8.5361

>T289870 WP_003409778.1 NZ_LR882499:c2206919-2206590 [Mycobacterium tuberculosis variant microti OV254]
VTALPARGEVWWCEMAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVVLEPGSDPIPRRSAVNLDSVESVSVA
VLVNRLGRLADIRMRAICTALEVAVDCSR

Download         Length: 330 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13560.07 Da        Isoelectric Point: 5.1519

>AT289870 WP_003409780.1 NZ_LR882499:c2207293-2206916 [Mycobacterium tuberculosis variant microti OV254]
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDE
ALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLK7

Antitoxin

Source ID Structure
AlphaFold DB G0TLK8

References