Detailed information of TA system TA028987

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1458690..1459899
• Replicon: chromosome
• Accession: NC_020509
• Organism: Helicobacter pylori OK310

Toxin (Protein)

• Gene name: panT
• Uniprot ID: M4ZQW0
• Locus tag: HPOK310_RS07100
• Protein ID: WP_015429520.1
• Coordinates: 1458690..1459472 (-)
• Length: 261 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: M5AAZ1
• Locus tag: HPOK310_RS07105
• Protein ID: WP_015429521.1
• Coordinates: 1459462..1459899 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOK310_RS07090	1456028..1457188	+	1161	WP_015429518.1	L-seryl-tRNA(Sec) selenium transferase	-
HPOK310_RS07095	1457276..1458463	+	1188	WP_015429519.1	transcription termination/antitermination protein NusA	-
HPOK310_RS07100	1458690..1459472	-	783	WP_015429520.1	hypothetical protein	Toxin
HPOK310_RS07105	1459462..1459899	-	438	WP_015429521.1	SocA family protein	Antitoxin
HPOK310_RS08095	1460125..1461750	-	1626	Protein_1362	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 261 a.a.
• Molecular weight: 30590.74 Da
• Isoelectric Point: 9.2968

>T28987 WP_015429520.1 NC_020509:c1459472-1458690 [Helicobacter pylori OK310]
MEIKEEDKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVTILSVIGFV
GERIDRQYKAQISKDFKRPR

Nucleotide

• Length: 783 bp

>T28987 NC_020509:c1459472-1458690 [Helicobacter pylori OK310]
ATGGAAATTAAAGAAGAGGATAAAGATAAAAAGCTAGAAAAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCTAG
TCAAAAAGATCAAATCATCAAAGATCTCAAAGAAATCTATGAAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAGGAAGTTGAAAGCATTAAGCCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATCAGGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAGCAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTATCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTACAATCCTATCTGTGATTGGTTTTGTG
GGAGAGAGAATTGATAGGCAATATAAAGCTCAGATTTCTAAAGATTTTAAAAGACCAAGATAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17289.35 Da
• Isoelectric Point: 5.7254

>AT28987 WP_015429521.1 NC_020509:c1459899-1459462 [Helicobacter pylori OK310]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVSREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINRSIEKCSEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT28987 NC_020509:c1459899-1459462 [Helicobacter pylori OK310]
ATGGTCAATACTTTGGAATTAGCAAAATATATTCTTAAGCATTCAAACAAAGAATTGAGCAACTTAGAATTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTTCAAGAGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCCAAAGAAGAAACACTC
TCACAAAATCTTAGAGAAGATGAACTTGAAACCATCAATCGCTCCATAGAAAAATGCAGCGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGTGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCAAAACAAGCAAATGGAAATTAA

Structures

Toxin

• AlphaFold DB: M4ZQW0

Antitoxin

• AlphaFold DB: M5AAZ1