Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1232819..1233450 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name mazF Uniprot ID A0A7U4F9D0
Locus tag JN986_RS05790 Protein ID WP_003405820.1
Coordinates 1232819..1233130 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TGZ7
Locus tag JN986_RS05795 Protein ID WP_003405836.1
Coordinates 1233130..1233450 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS05770 1228301..1229725 - 1425 WP_003405805.1 class II fumarate hydratase -
JN986_RS05775 1229756..1230844 - 1089 WP_202592755.1 class II fructose-bisphosphatase -
JN986_RS05780 1230900..1231544 + 645 WP_003915494.1 DUF4245 domain-containing protein -
JN986_RS05785 1231551..1232707 - 1157 Protein_1139 AI-2E family transporter -
JN986_RS05790 1232819..1233130 - 312 WP_003405820.1 type II toxin-antitoxin system toxin endoribonuclease MazF3 Toxin
JN986_RS05795 1233130..1233450 - 321 WP_003405836.1 type II toxin-antitoxin system antitoxin MazE3 Antitoxin
JN986_RS05800 1233460..1234985 + 1526 Protein_1142 carboxylesterase/lipase family protein -
JN986_RS05805 1235003..1236115 - 1113 WP_003405840.1 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase -
JN986_RS05810 1236125..1236382 - 258 WP_003405844.1 exodeoxyribonuclease VII small subunit -
JN986_RS05815 1236372..1237619 - 1248 WP_003405846.1 exodeoxyribonuclease VII large subunit -
JN986_RS05820 1237616..1238254 - 639 WP_003898730.1 lipid droplet-associated protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11061.82 Da        Isoelectric Point: 4.9371

>T289860 WP_003405820.1 NZ_LR882499:c1233130-1232819 [Mycobacterium tuberculosis variant microti OV254]
MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYL
LASQEPALAEAIGNAFDLDWVVA

Download         Length: 312 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11394.83 Da        Isoelectric Point: 5.1236

>AT289860 WP_003405836.1 NZ_LR882499:c1233450-1233130 [Mycobacterium tuberculosis variant microti OV254]
MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEI
LATNTSATGDLDTLAGHCARTALDID

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4F9D0

Antitoxin

Source ID Structure
AlphaFold DB G0TGZ7

References