Detailed information of TA system TA028986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 902224..902794
• Replicon: chromosome
• Accession: NC_020509
• Organism: Helicobacter pylori OK310

Toxin (Protein)

• Gene name: relE
• Uniprot ID: M4ZNL7
• Locus tag: HPOK310_RS04340
• Protein ID: WP_015429138.1
• Coordinates: 902224..902496 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4ZPF7
• Locus tag: HPOK310_RS04345
• Protein ID: WP_015429139.1
• Coordinates: 902483..902794 (-)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOK310_RS04320	898871..899638	-	768	WP_015429136.1	ABC transporter ATP-binding protein	-
HPOK310_RS04325	899638..900618	-	981	WP_000921438.1	iron ABC transporter permease	-
HPOK310_RS04330	900611..901453	-	843	WP_015429137.1	SDR family oxidoreductase	-
HPOK310_RS04335	901593..902117	+	525	WP_001135602.1	acyl-CoA thioesterase	-
HPOK310_RS04340	902224..902496	-	273	WP_015429138.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HPOK310_RS04345	902483..902794	-	312	WP_015429139.1	hypothetical protein	Antitoxin
HPOK310_RS04350	903114..905321	-	2208	WP_015429140.1	Hop family adhesin BabA	-
HPOK310_RS04370	905829..906350	+	522	WP_041199930.1	hypothetical protein	-
HPOK310_RS04375	906301..907413	-	1113	WP_015429141.1	hydrogenase formation protein HypD	-
HPOK310_RS04380	907441..907677	-	237	WP_000335459.1	HypC/HybG/HupF family hydrogenase formation chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10585.59 Da
• Isoelectric Point: 9.7265

>T28986 WP_015429138.1 NC_020509:c902496-902224 [Helicobacter pylori OK310]
MLMVETSKKFDKDLKILVKNGFDLKLLYKVVENLAKEQPLDPKYKDHPLKGALKDFRECHLKPDLLLVYQIKKQENTLFL
VRLGSHSELF

Nucleotide

• Length: 273 bp

>T28986 NC_020509:c902496-902224 [Helicobacter pylori OK310]
ATGCTGATGGTTGAAACTAGTAAAAAATTTGATAAGGATCTTAAAATTCTTGTTAAAAATGGGTTTGATTTAAAGCTTTT
ATATAAAGTGGTTGAAAATTTAGCCAAAGAGCAACCCCTAGATCCCAAATATAAAGACCACCCGCTCAAAGGCGCTTTAA
AAGATTTTAGGGAATGCCACCTGAAACCGGATTTATTGCTTGTCTATCAAATTAAAAAACAAGAAAACACCCTCTTTTTA
GTAAGACTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12232.07 Da
• Isoelectric Point: 10.2825

>AT28986 WP_015429139.1 NC_020509:c902794-902483 [Helicobacter pylori OK310]
MPNSPTKKDYTQYSEKQLFNFLNSIKTKQKRALEKLKEIQAQKQRIKKALQFKALHLTENGYTIEEEREILARAKDTKNH
LCFKSVEDFKKHCENLRFKNADG

Nucleotide

• Length: 312 bp

>AT28986 NC_020509:c902794-902483 [Helicobacter pylori OK310]
ATGCCCAACTCTCCCACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTTTTAAATTCTATCAAGAC
CAAACAAAAAAGAGCGTTAGAAAAATTGAAAGAAATCCAAGCTCAAAAACAAAGAATTAAAAAAGCGCTCCAATTTAAAG
CGCTCCATTTAACCGAAAACGGATACACCATAGAAGAAGAGCGAGAAATCTTAGCAAGGGCTAAAGACACCAAGAACCAC
CTTTGTTTTAAAAGCGTAGAGGATTTTAAAAAGCATTGTGAAAACTTAAGATTTAAAAATGCTGATGGTTGA

Structures

Toxin

• AlphaFold DB: M4ZNL7

Antitoxin

• AlphaFold DB: M4ZPF7