Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1025615..1026588 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag JN986_RS04820 Protein ID WP_003404756.1
Coordinates 1026088..1026588 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID G0TFR4
Locus tag JN986_RS04815 Protein ID WP_003404754.1
Coordinates 1025615..1026091 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS04795 1021462..1022733 - 1272 WP_003404747.1 PPE family protein -
JN986_RS04800 1022748..1023047 - 300 WP_003404748.1 PE family protein -
JN986_RS04805 1023491..1025272 + 1782 WP_003404749.1 BCCT family transporter -
JN986_RS04810 1025269..1025526 + 258 WP_003404750.1 hypothetical protein -
JN986_RS04815 1025615..1026091 + 477 WP_003404754.1 DUF1778 domain-containing protein Antitoxin
JN986_RS04820 1026088..1026588 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
JN986_RS04830 1026901..1028220 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
JN986_RS04835 1028508..1029089 + 582 WP_105799544.1 IS607-like element IS1535 family transposase -
JN986_RS04840 1029089..1030747 + 1659 WP_105799545.1 IS607 family element transposase accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1025269..1071185 45916


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T289858 WP_003404756.1 NZ_LR882499:1026088-1026588 [Mycobacterium tuberculosis variant microti OV254]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17357.95 Da        Isoelectric Point: 11.2467

>AT289858 WP_003404754.1 NZ_LR882499:1025615-1026091 [Mycobacterium tuberculosis variant microti OV254]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB G0TFR4

References