Detailed information of TA system TA028985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1513867..1515058
• Replicon: chromosome
• Accession: NC_020508
• Organism: Helicobacter pylori OK113

Toxin (Protein)

• Gene name: panT
• Uniprot ID: M4ZL44
• Locus tag: HPOK113_RS07370
• Protein ID: WP_015428396.1
• Coordinates: 1513867..1514631 (-)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: M4ZLQ8
• Locus tag: HPOK113_RS07375
• Protein ID: WP_015428397.1
• Coordinates: 1514621..1515058 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HPOK113_RS07360	1511194..1512354	+	1161	WP_015428394.1	L-seryl-tRNA(Sec) selenium transferase	-
HPOK113_RS07365	1512450..1513637	+	1188	WP_015428395.1	transcription termination/antitermination protein NusA	-
HPOK113_RS07370	1513867..1514631	-	765	WP_015428396.1	hypothetical protein	Toxin
HPOK113_RS07375	1514621..1515058	-	438	WP_015428397.1	SocA family protein	Antitoxin
HPOK113_RS07380	1515281..1516912	-	1632	Protein_1410	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29783.87 Da
• Isoelectric Point: 6.7314

>T28985 WP_015428396.1 NC_020508:c1514631-1513867 [Helicobacter pylori OK113]
MEAKEEDKDKKLEEIIVLLCEEGDLSSQKDQIIKDLEEIYTGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEKKDKQENFFKKPIFWFNLMVTILFMIGFF
GELHIIQKLVSKYL

Nucleotide

• Length: 765 bp

>T28985 NC_020508:c1514631-1513867 [Helicobacter pylori OK113]
ATGGAAGCTAAAGAAGAGGATAAAGATAAAAAGCTAGAAGAAATTATTGTATTGCTGTGCGAAGAGGGGGATTTGTCTAG
CCAAAAAGATCAAATCATCAAAGATCTCGAAGAAATCTATACAGGAGAATACAAGCATAAATACTCAAAAATCACAACTA
TTATTTTAAATTCCACAAGGGATAAAGAGCAAGCCTTTATGATGCTCACACAAAATATAAAGACACTCAAAGAGATTCAA
GATAATAAAGAAGTTGAAAGCATTAAACCAAAACTAGAAAAGCTTTATGATCACATGAATTTAGAGTGTATCAGACTGCA
AGATTTTGATGAGAAAATGAGTAGAGTTAAAGATGTTTCTATAAAGTTAGAAGATGATCTAAATAAAAACTATAAAAAAT
TAAGCGAAGAATTGAATAAGCAGCAAACGCAATACATAACAATTTTAGGTATTTTTGCCTCTATTGTTTTAACATTTGTT
GGGGGATTGGCGTTTTCCACTTCTGTTTTATCAAATATTGACAAAGCGAACGCCTATCGTTTGGTTTTTGTTATGGCTTT
TATAGCTTTATTTTTTGGGAATATTTTGTATCTGCTTTTTTCTTTTTTGTCAAAAATATCCTTATCAAAAGAGAAAAAAG
ATAAACAAGAAAATTTTTTCAAAAAACCTATTTTTTGGTTTAATCTAATGGTTACAATTCTATTTATGATTGGTTTTTTT
GGAGAATTGCATATAATACAAAAATTAGTTTCTAAATATCTTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17203.31 Da
• Isoelectric Point: 5.7154

>AT28985 WP_015428397.1 NC_020508:c1515058-1514621 [Helicobacter pylori OK113]
MINALELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINCSIQKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGS

Nucleotide

• Length: 438 bp

>AT28985 NC_020508:c1515058-1514621 [Helicobacter pylori OK113]
ATGATCAATGCTTTGGAATTAGCAAAATATATTCTTAAGCATTCCAACAAAGAATTGAGCAACTTAGAGTTGCAAAAAAC
TTTGTATTTCACAGAGCTTGACTATATTAAAAAGTTTGACAAACACCTAGTTTCTGATGATTTTGAAGCTTGGAAATACG
GGCCTGTTGCAAGAGAAGTGTATTATGAATATCGCAATTATGGTGCCAATTCTATTGACAAACCCAAAGAAGAAACGCTC
TCACAAAATCTTAGAGAAGATGAACTTGAAACCATCAATTGCTCCATACAAAAATGCAACGAAAAATCCTATTGGGATTT
AGTGAAAGAGAGTCATAAAGAAGATGGCGCTTGGCATAAAAGCTTCAAAGAAGATAGAAAAGAAATCATTAGCAAAGATT
TGATCAAACAAGAAGCCAAACAAGCAAATGGAAGCTAA

Structures

Toxin

• AlphaFold DB: M4ZL44

Antitoxin

• AlphaFold DB: M4ZLQ8