Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/AbrB(antitoxin) |
Location | 698794..699440 | Replicon | chromosome |
Accession | NZ_LR882499 | ||
Organism | Mycobacterium tuberculosis variant microti OV254 isolate vole |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ88 |
Locus tag | JN986_RS03115 | Protein ID | WP_003403137.1 |
Coordinates | 698794..699207 (-) | Length | 138 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TQ89 |
Locus tag | JN986_RS03120 | Protein ID | WP_003403139.1 |
Coordinates | 699204..699440 (-) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN986_RS03095 | 694877..696427 | + | 1551 | WP_003403119.1 | MCE family protein | - |
JN986_RS03100 | 696479..696871 | - | 393 | WP_003403122.1 | type II toxin-antitoxin system toxin ribonuclease C4 | - |
JN986_RS03105 | 696868..697125 | - | 258 | WP_003403125.1 | type II toxin-antitoxin system antitoxin VapB4 | - |
JN986_RS03110 | 697308..698543 | - | 1236 | WP_003403128.1 | ATP-binding protein | - |
JN986_RS03115 | 698794..699207 | - | 414 | WP_003403137.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
JN986_RS03120 | 699204..699440 | - | 237 | WP_003403139.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
JN986_RS03125 | 699544..700050 | - | 507 | WP_003900973.1 | two component system sensor kinase HK1 | - |
JN986_RS03130 | 700164..700694 | - | 531 | WP_003917320.1 | two component system sensor kinase HK2 | - |
JN986_RS03135 | 700678..701373 | - | 696 | WP_003918099.1 | two-component system response regulator TcrA | - |
JN986_RS03140 | 701496..701807 | + | 312 | WP_003403164.1 | hypothetical protein | - |
JN986_RS03145 | 701879..702829 | + | 951 | WP_003907436.1 | DUF1259 domain-containing protein | - |
JN986_RS03150 | 703070..703654 | + | 585 | WP_003403171.1 | IS607-like element IS1536 family transposase | - |
JN986_RS03155 | 703656..704369 | + | 714 | Protein_625 | IS607 family element transposase accessory protein TnpB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 138 a.a. Molecular weight: 14786.14 Da Isoelectric Point: 8.1405
>T289847 WP_003403137.1 NZ_LR882499:c699207-698794 [Mycobacterium tuberculosis variant microti OV254]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA
Download Length: 414 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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