289843

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 365077..365720 Replicon chromosome
Accession NZ_LR882499
Organism Mycobacterium tuberculosis variant microti OV254 isolate vole

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB8
Locus tag JN986_RS01595 Protein ID WP_003401566.1
Coordinates 365295..365720 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O07227
Locus tag JN986_RS01590 Protein ID WP_003401563.1
Coordinates 365077..365298 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN986_RS01565 360148..360951 - 804 WP_003401540.1 hypothetical protein -
JN986_RS01570 360961..362358 - 1398 WP_003401544.1 sulfatase -
JN986_RS01575 362537..364360 + 1824 WP_105826467.1 PE family protein -
JN986_RS01580 364503..364730 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family -
JN986_RS01585 364727..365029 + 303 WP_003401560.1 toxin-antitoxin system toxin -
JN986_RS01590 365077..365298 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
JN986_RS01595 365295..365720 + 426 WP_003401566.1 PIN domain nuclease Toxin
JN986_RS01600 365856..366488 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
JN986_RS01605 366485..367393 + 909 WP_003900117.1 SDR family NAD(P)-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-37)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15713.90 Da        Isoelectric Point: 5.6002

>T289843 WP_003401566.1 NZ_LR882499:365295-365720 [Mycobacterium tuberculosis variant microti OV254]
VTDQRWLIDKSALVRLTDSPDMEIWSNRIERGLVHITGVTRLEVGFSAECGEIARREFREPPLSAMPVEYLTPRIEDRAL
EVQTLLADRGHHRGPSIPDLLIAATAELSGLTVLHVDKDFDAIAALTGQKTERLTHRPPSA

Download         Length: 426 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8088.31 Da        Isoelectric Point: 10.7177

>AT289843 WP_003401563.1 NZ_LR882499:365077-365298 [Mycobacterium tuberculosis variant microti OV254]
MSDVLIRDIPDDVLASLDAIAARLGLSRTEYIRRRLAQDAQTARVTVTAADLRRLRGAVAGLGDPELMRQAWR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3H87

Antitoxin

Source ID Structure
AlphaFold DB A0A829CG48

References