28984

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 955126..955750 Replicon chromosome
Accession NC_020508
Organism Helicobacter pylori OK113

Toxin (Protein)


Gene name relE Uniprot ID A0A1Q2PIC7
Locus tag HPOK113_RS04575 Protein ID WP_000916176.1
Coordinates 955126..955392 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID M5A5L1
Locus tag HPOK113_RS04580 Protein ID WP_015427988.1
Coordinates 955373..955750 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPOK113_RS04555 951775..952542 - 768 WP_015427986.1 ABC transporter ATP-binding protein -
HPOK113_RS04560 952542..953522 - 981 WP_000921438.1 iron ABC transporter permease -
HPOK113_RS04565 953515..954357 - 843 WP_015427987.1 SDR family oxidoreductase -
HPOK113_RS04570 954497..955021 + 525 WP_001135602.1 acyl-CoA thioesterase -
HPOK113_RS04575 955126..955392 - 267 WP_000916176.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPOK113_RS04580 955373..955750 - 378 WP_015427988.1 hypothetical protein Antitoxin
HPOK113_RS04590 956155..958380 - 2226 WP_015427989.1 Hop family adhesin BabA -
HPOK113_RS04605 958773..959387 + 615 WP_015427990.1 hypothetical protein -
HPOK113_RS04610 959338..960450 - 1113 WP_015427991.1 hydrogenase formation protein HypD -
HPOK113_RS04615 960469..960705 - 237 WP_000335459.1 HypC/HybG/HupF family hydrogenase formation chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10245.13 Da        Isoelectric Point: 9.9517

>T28984 WP_000916176.1 NC_020508:c955392-955126 [Helicobacter pylori OK113]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKGDELILVR
LGSHSELF

Download         Length: 267 bp

>T28984 NC_020508:c955392-955126 [Helicobacter pylori OK113]
GTGTTGAAACTCAATCTTAAAAAATCTTTTCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATAAGGTCATTCTGTCTTTGAGAAAAAAAGAACCGCTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTACTTGTTTATTTGGTGAAAGGTGATGAGCTTATTTTAGTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14710.64 Da        Isoelectric Point: 7.7778

>AT28984 WP_015427988.1 NC_020508:c955750-955373 [Helicobacter pylori OK113]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDALNKETDLIVEDFSSYSDERKRALGVETQS

Download         Length: 378 bp

>AT28984 NC_020508:c955750-955373 [Helicobacter pylori OK113]
ATGCCTAATTCTCCCACCAAAAAAGACTACACGCAATACAGCGAAAAACAGCTTTTTAACTTAATCAACCAATTGGAGCA
AAAAATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTAAACAAAGAAACCGATTTGATTGTTGAGGA
TTTTTCTAGTTATAGCGATGAAAGAAAAAGGGCGTTAGGTGTTGAAACTCAATCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q2PIC7

Antitoxin

Source ID Structure
AlphaFold DB M5A5L1

References