289836

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3709945..3710619 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JN980_RS17305 Protein ID WP_105799814.1
Coordinates 3709945..3710373 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JN980_RS17310 Protein ID WP_003417286.1
Coordinates 3710377..3710619 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS17280 3705767..3706168 - 402 WP_003417264.1 cytidine deaminase -
JN980_RS17285 3706309..3706743 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
JN980_RS17290 3706740..3707174 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JN980_RS17295 3707303..3709075 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
JN980_RS17300 3709075..3709866 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JN980_RS17305 3709945..3710373 - 429 WP_105799814.1 type II toxin-antitoxin system VapC family toxin Toxin
JN980_RS17310 3710377..3710619 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
JN980_RS17315 3710741..3711355 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JN980_RS17320 3711352..3712017 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JN980_RS17325 3712018..3712551 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JN980_RS17330 3712548..3712922 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
JN980_RS17335 3713019..3714083 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15751.08 Da        Isoelectric Point: 8.3191

>T289836 WP_105799814.1 NZ_LR882498:c3710373-3709945 [Mycobacterium tuberculosis variant microti]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGCASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT289836 WP_003417286.1 NZ_LR882498:c3710619-3710377 [Mycobacterium tuberculosis variant microti]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References