Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/PIN(toxin) |
Location | 3180495..3181182 | Replicon | chromosome |
Accession | NZ_LR882498 | ||
Organism | Mycobacterium tuberculosis variant microti strain Maus III isolate human |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P65044 |
Locus tag | JN980_RS14940 | Protein ID | WP_003414624.1 |
Coordinates | 3180739..3181182 (+) | Length | 148 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | G0TFH0 |
Locus tag | JN980_RS14935 | Protein ID | WP_003414620.1 |
Coordinates | 3180495..3180752 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JN980_RS14915 | 3175815..3176669 | - | 855 | WP_003899516.1 | GNAT family N-acetyltransferase | - |
JN980_RS14920 | 3176725..3177888 | - | 1164 | WP_003899517.1 | flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase | - |
JN980_RS14925 | 3177905..3179119 | - | 1215 | WP_003414610.1 | zinc metalloprotease Rip | - |
JN980_RS14930 | 3179127..3180368 | - | 1242 | WP_003414613.1 | 1-deoxy-D-xylulose-5-phosphate reductoisomerase | - |
JN980_RS14935 | 3180495..3180752 | + | 258 | WP_003414620.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
JN980_RS14940 | 3180739..3181182 | + | 444 | WP_003414624.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
JN980_RS14945 | 3181262..3181924 | + | 663 | WP_003414630.1 | cell surface glycolipoprotein Mpt83 | - |
JN980_RS14950 | 3182020..3182211 | + | 192 | WP_105799616.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
JN980_RS14955 | 3182543..3184291 | + | 1749 | WP_003912869.1 | cytochrome c biogenesis protein DipZ | - |
JN980_RS14960 | 3184387..3184968 | + | 582 | WP_003414644.1 | fasciclin domain-containing protein | - |
JN980_RS14965 | 3185068..3185334 | + | 267 | WP_031652375.1 | DUF2631 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16595.72 Da Isoelectric Point: 6.4890
>T289834 WP_003414624.1 NZ_LR882498:3180739-3181182 [Mycobacterium tuberculosis variant microti]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL
Download Length: 444 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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