Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 3131066..3132840 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name abiEi Uniprot ID P71626
Locus tag JN980_RS14690 Protein ID WP_003414409.1
Coordinates 3131066..3131950 (-) Length 295 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID P71625
Locus tag JN980_RS14695 Protein ID WP_003414414.1
Coordinates 3131953..3132840 (-) Length 296 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS14670 3126321..3126695 - 375 WP_003414296.1 type III-A CRISPR-associated protein Csm2 -
JN980_RS14675 3126692..3129130 - 2439 WP_003900580.1 type III-A CRISPR-associated protein Cas10/Csm1 -
JN980_RS14680 3129127..3129915 - 789 WP_003917092.1 CRISPR-associated endoribonuclease Cas6 -
JN980_RS14685 3130249..3130794 - 546 WP_003904931.1 DUF1802 family protein -
JN980_RS14690 3131066..3131950 - 885 WP_003414409.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
JN980_RS14695 3131953..3132840 - 888 WP_003414414.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
JN980_RS14700 3133145..3133690 - 546 WP_003899500.1 DUF1802 family protein -
JN980_RS14705 3133687..3133956 - 270 WP_003414489.1 DUF2277 family protein -
JN980_RS14710 3133977..3134369 - 393 WP_003414492.1 type II toxin-antitoxin system VapC family toxin -
JN980_RS14715 3134366..3134581 - 216 WP_003414495.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JN980_RS14720 3134628..3135377 + 750 WP_003414497.1 enoyl-CoA hydratase -
JN980_RS14725 3135456..3136538 - 1083 WP_003414499.1 ABC transporter ATP-binding protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 295 a.a.        Molecular weight: 33056.72 Da        Isoelectric Point: 7.1520

>T289831 WP_003414409.1 NZ_LR882498:c3131950-3131066 [Mycobacterium tuberculosis variant microti]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS

Download         Length: 885 bp


Antitoxin


Download         Length: 296 a.a.        Molecular weight: 32315.19 Da        Isoelectric Point: 9.4723

>AT289831 WP_003414414.1 NZ_LR882498:c3132840-3131953 [Mycobacterium tuberculosis variant microti]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGQALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA

Download         Length: 888 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6Y56


Antitoxin

Source ID Structure
AlphaFold DB A0A829CBU9

References