289822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2855691..2856331 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ08
Locus tag JN980_RS13155 Protein ID WP_003412970.1
Coordinates 2855691..2856110 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ09
Locus tag JN980_RS13160 Protein ID WP_003412975.1
Coordinates 2856107..2856331 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS13125 2851276..2851998 - 723 WP_003412957.1 DUF1906 domain-containing protein -
JN980_RS13130 2852515..2852742 + 228 WP_003412960.1 type II toxin-antitoxin system VapB family antitoxin -
JN980_RS13135 2852739..2853140 + 402 WP_003412963.1 PIN domain-containing protein -
JN980_RS13140 2853175..2854095 - 921 WP_003412965.1 restriction endonuclease -
JN980_RS13145 2854436..2854681 - 246 WP_071854223.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JN980_RS13150 2854740..2855690 + 951 WP_003911916.1 Lsr2 family protein -
JN980_RS13155 2855691..2856110 - 420 WP_003412970.1 type II toxin-antitoxin system VapC family toxin Toxin
JN980_RS13160 2856107..2856331 - 225 WP_003412975.1 antitoxin VapB39 Antitoxin
JN980_RS13165 2856362..2859206 - 2845 Protein_2596 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
JN980_RS13170 2859278..2859679 - 402 WP_003412981.1 hypothetical protein -
JN980_RS13175 2859679..2860149 - 471 WP_003412985.1 transcription antitermination factor NusB -
JN980_RS13180 2860152..2860715 - 564 WP_003412989.1 elongation factor P -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14732.70 Da        Isoelectric Point: 6.7519

>T289822 WP_003412970.1 NZ_LR882498:c2856110-2855691 [Mycobacterium tuberculosis variant microti]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Download         Length: 420 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7993.94 Da        Isoelectric Point: 4.0057

>AT289822 WP_003412975.1 NZ_LR882498:c2856331-2856107 [Mycobacterium tuberculosis variant microti]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ08

Antitoxin

Source ID Structure
AlphaFold DB G0TQ09

References