289815

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2235938..2236524 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name mazF Uniprot ID G0TLY3
Locus tag JN980_RS10305 Protein ID WP_003410010.1
Coordinates 2235938..2236282 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL58
Locus tag JN980_RS10310 Protein ID WP_003410014.1
Coordinates 2236276..2236524 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS10270 2231138..2232049 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN980_RS10275 2232158..2232757 + 600 WP_003409989.1 L-lysine exporter -
JN980_RS10280 2233173..2233601 + 429 WP_003409992.1 cellulose-binding protein -
JN980_RS10285 2234372..2234932 - 561 WP_003410001.1 RES family NAD+ phosphorylase -
JN980_RS10290 2234929..2235270 - 342 WP_003410003.1 DUF2384 domain-containing protein -
JN980_RS10295 2235356..2235613 + 258 WP_003410006.1 hypothetical protein -
JN980_RS10300 2235514..2235849 - 336 WP_003410009.1 dehydrogenase -
JN980_RS10305 2235938..2236282 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 Toxin
JN980_RS10310 2236276..2236524 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family Antitoxin
JN980_RS10315 2236624..2238939 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JN980_RS10320 2238936..2239208 - 273 WP_003410017.1 DUF1490 family protein -
JN980_RS10325 2239261..2239617 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -
JN980_RS10330 2239774..2240541 + 768 WP_003410019.1 hemerythrin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12230.12 Da        Isoelectric Point: 9.8887

>T289815 WP_003410010.1 NZ_LR882498:c2236282-2235938 [Mycobacterium tuberculosis variant microti]
VVISRAEIYWADLGPPSGSQPAKRRPVLVIQSDPYNASRLATVIAAVITSNTALAAMPGNVFLPATTTRLPRDSVVNVTA
IVTLNKTDLTDRVGEVPASLMHEVDRGLRRVLDL

Download         Length: 345 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.34 Da        Isoelectric Point: 4.3757

>AT289815 WP_003410014.1 NZ_LR882498:c2236524-2236276 [Mycobacterium tuberculosis variant microti]
MKTAISLPDETFDRVSRRASELGMSRSEFFTKAAQRYLHELDAQLLTGQIDRALESIHGTDEAEALAVANAYRVLETMDD
EW

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5HK3
PDB 5HK0
PDB 5HKC

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAW9

References