289814

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mbcAT/RES-TIGR02293
Location 2234372..2235270 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name mbcT Uniprot ID P64908
Locus tag JN980_RS10285 Protein ID WP_003410001.1
Coordinates 2234372..2234932 (-) Length 187 a.a.

Antitoxin (Protein)


Gene name mbcA Uniprot ID P64910
Locus tag JN980_RS10290 Protein ID WP_003410003.1
Coordinates 2234929..2235270 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS10260 2230055..2230708 - 654 WP_003409976.1 cutinase Cfp21 -
JN980_RS10265 2230823..2231053 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN980_RS10270 2231138..2232049 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN980_RS10275 2232158..2232757 + 600 WP_003409989.1 L-lysine exporter -
JN980_RS10280 2233173..2233601 + 429 WP_003409992.1 cellulose-binding protein -
JN980_RS10285 2234372..2234932 - 561 WP_003410001.1 RES family NAD+ phosphorylase Toxin
JN980_RS10290 2234929..2235270 - 342 WP_003410003.1 DUF2384 domain-containing protein Antitoxin
JN980_RS10295 2235356..2235613 + 258 WP_003410006.1 hypothetical protein -
JN980_RS10300 2235514..2235849 - 336 WP_003410009.1 dehydrogenase -
JN980_RS10305 2235938..2236282 - 345 WP_003410010.1 type II toxin-antitoxin system toxin endoribonuclease MazF6 -
JN980_RS10310 2236276..2236524 - 249 WP_003410014.1 ribbon-helix-helix protein, CopG family -
JN980_RS10315 2236624..2238939 - 2316 WP_003899120.1 cation transporter ATPase CptG -
JN980_RS10320 2238936..2239208 - 273 WP_003410017.1 DUF1490 family protein -
JN980_RS10325 2239261..2239617 - 357 WP_003410018.1 Cd(II)/Pb(II)-sensing metalloregulatory transcriptional regulator CmtR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(25-148)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-110)


Sequences

Toxin        


Download         Length: 187 a.a.        Molecular weight: 20248.70 Da        Isoelectric Point: 4.5091

>T289814 WP_003410001.1 NZ_LR882498:c2234932-2234372 [Mycobacterium tuberculosis variant microti]
VSDALDEGLVQRIDARGTIEWSETCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERAAQAASTT
AEKMLEAAYRLHTIDVTDLAVLDLTTPQAREAVGLENDDIYGDDWSGCQAVGHAAWFLHMQGVLVPAAGGVGLVVTAYEQ
RTRPGQLQLRQSVDLTPALYQELRAT

Download         Length: 561 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12488.33 Da        Isoelectric Point: 4.8359

>AT289814 WP_003410003.1 NZ_LR882498:c2235270-2234929 [Mycobacterium tuberculosis variant microti]
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FKG

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAE4

References