Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2227560..2228248 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag JN980_RS10245 Protein ID WP_003409958.1
Coordinates 2227560..2227979 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag JN980_RS10250 Protein ID WP_003409968.1
Coordinates 2227988..2228248 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS10220 2222567..2222872 + 306 Protein_2017 ABC transporter permease -
JN980_RS10225 2223094..2223903 + 810 WP_202582023.1 class I SAM-dependent methyltransferase -
JN980_RS10230 2223866..2225311 - 1446 WP_003409946.1 APC family permease -
JN980_RS10235 2225490..2226176 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
JN980_RS10240 2226367..2227335 - 969 WP_003409956.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
JN980_RS10245 2227560..2227979 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
JN980_RS10250 2227988..2228248 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN980_RS10255 2228391..2230067 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
JN980_RS10260 2230055..2230708 - 654 WP_003409976.1 cutinase Cfp21 -
JN980_RS10265 2230823..2231053 + 231 WP_003409980.1 DUF167 domain-containing protein -
JN980_RS10270 2231138..2232049 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
JN980_RS10275 2232158..2232757 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T289813 WP_003409958.1 NZ_LR882498:c2227979-2227560 [Mycobacterium tuberculosis variant microti]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT289813 WP_003409968.1 NZ_LR882498:c2228248-2227988 [Mycobacterium tuberculosis variant microti]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References