Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1695261..1695877 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag JN980_RS07850 Protein ID WP_003407593.1
Coordinates 1695560..1695877 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag JN980_RS07845 Protein ID WP_003900349.1
Coordinates 1695261..1695563 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS07835 1691147..1692994 + 1848 WP_202582012.1 methylmalonyl-CoA mutase small subunit -
JN980_RS07840 1692995..1695247 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
JN980_RS07845 1695261..1695563 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
JN980_RS07850 1695560..1695877 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
JN980_RS07855 1695874..1696878 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
JN980_RS07860 1696931..1698220 + 1290 WP_003407599.1 serine hydrolase -
JN980_RS07865 1698293..1699066 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
JN980_RS07870 1699124..1699315 - 192 WP_003407609.1 dodecin family protein -
JN980_RS07875 1699346..1699570 - 225 WP_160522526.1 NUDIX domain-containing protein -
JN980_RS07880 1699840..1700868 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T289806 WP_003407593.1 NZ_LR882498:1695560-1695877 [Mycobacterium tuberculosis variant microti]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT289806 WP_003900349.1 NZ_LR882498:1695261-1695563 [Mycobacterium tuberculosis variant microti]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References