289801

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1243030..1243598 Replicon chromosome
Accession NZ_LR882498
Organism Mycobacterium tuberculosis variant microti strain Maus III isolate human

Toxin (Protein)


Gene name vapC Uniprot ID G0TH08
Locus tag JN980_RS05850 Protein ID WP_003405865.1
Coordinates 1243224..1243598 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TH07
Locus tag JN980_RS05845 Protein ID WP_003405863.1
Coordinates 1243030..1243227 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JN980_RS05825 1239071..1239709 - 639 WP_003898730.1 lipid droplet-associated protein -
JN980_RS05830 1239799..1240806 + 1008 WP_003405853.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
JN980_RS05835 1240823..1241806 - 984 WP_003898731.1 hypothetical protein -
JN980_RS05840 1241869..1242942 + 1074 WP_105799741.1 redox-regulated ATPase YchF -
JN980_RS05845 1243030..1243227 + 198 WP_003405863.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JN980_RS05850 1243224..1243598 + 375 WP_003405865.1 type II toxin-antitoxin system VapC family toxin Toxin
JN980_RS05855 1243801..1244499 + 699 WP_003898733.1 hypothetical protein -
JN980_RS05860 1244617..1244802 + 186 WP_003901093.1 hypothetical protein -
JN980_RS05865 1244729..1245004 - 276 WP_003405867.1 hypothetical protein -
JN980_RS05870 1245247..1245570 + 324 WP_003405871.1 antibiotic biosynthesis monooxygenase -
JN980_RS05875 1245585..1246295 - 711 WP_003911399.1 hypothetical protein -
JN980_RS05880 1246317..1246526 + 210 WP_003911400.1 hypothetical protein -
JN980_RS05885 1246478..1247185 - 708 Protein_1160 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-111)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13444.56 Da        Isoelectric Point: 5.1881

>T289801 WP_003405865.1 NZ_LR882498:1243224-1243598 [Mycobacterium tuberculosis variant microti]
VILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGR
GLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS

Download         Length: 375 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6973.03 Da        Isoelectric Point: 11.7327

>AT289801 WP_003405863.1 NZ_LR882498:1243030-1243227 [Mycobacterium tuberculosis variant microti]
MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TH08

Antitoxin

Source ID Structure
AlphaFold DB G0TH07

References